Abstract
In order to investigate the antibacterial activity of acylpentapeptides, the compounds containing the partial structure of lysine-colistin were synthesized by the acylation of pentapeptide obtained from tripeptide and dipeptide by dicyclohexylcarbodiimide reaction. Acid chlorides of 6-methyloctanoic acid (a component of colistin) and eleven other kinds of acid were employed as the acylating agent. It was proved that five acylpentapeptides have about one-half the antibacterial activity of colistin sulfate against gramnagative bacteria.
