Abstract
The effect of additives on the stabilization, i.e., retardation of hydrolysis of aminoalkyl esters of phenylacetic acid [chemical formula] was examined. Among the esters I(R1=H, R2=H), II(R1=H, R2=CH3), III(R1=CH3, R2=H), IV(R1=n-C3H7, R2=H), V(R1=n-C4H9, R2=H), VI(R1=sec-C4H9, R2=H), VII(R1=sec-C4H9, R2=CH3), VIII(R1=C6H5, R2=H), IX(R1=m-CH3O-C6H4, R2=H), the hydrolysis rate of VI was remarkably decreased by the presenced of nicotinamide, N-(hydroxyethyl) lactamide, and glutathione. The effect of these additives on the ester hydrolysis rate was studied in terms of complexation. The complex formation was examined by a kinetic procedure, solubility, partition, ultraviolet spectrum, and nuclear magnetic resonance spectrum. Among these, kinetic procedure and solubility method showed the formation of 1 : 1 complex.
