YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Quinolizine誘導体の研究(第10報)Cyclazine類の合成とその反応 その3
粟屋 博義間瀬 千香暁富永 義則夏木 令子松田 芳郎小林 五郎
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1975 年 95 巻 1 号 p. 13-16

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1-Cyano-4-imino-2-methylthio-4H-pyrido [1, 2-c] pyrimidine (III) was obtained from 2-pyridineacetonitrile and dimethyl cyanamidedithiocarboxylate, and the reactivity of III was examined. The reaction of III with an amine, acetic anhydride, and methyl iodide gave the corresponding products (X, IV, and V), while III or 3-cyano-4-imino-4H-pyrido [1, 2-α] pyrimidine (IX) and dimethyl acetylenedicarboxylate afforded 1, 9-diazacycl-[3, 3, 3] azine derivative (XII) and 1, 4-diazacycl [3, 3, 3] azine derivative (XIII). The reaction of XII or XIII with an amine resulted in the formation of corresponding products (XIV, XV).
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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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