Studies on Diphenylmethane Derivatives. III. Synthesis of N-Substituted-1-(2, 3-dimethoxyphenyl)-1-(2-, 3- or 4-substituted phenyl) methylamine Derivatives

Abstract

N-Alkyl-1-(2, 3-dimethoxyphenyl)-1-(2-, 3-, or 4-substituted phenyl) methylamines (XI-XLI) were synthesized from 2, 3-dimethoxybenzaldehyde (II) using the Grignard reaction, followed by halogenation and amination with various alkylamines. Of the compounds synthesized and tested, XXI, XXII, and XXVII were found to possess a weak antitussive activity, and XI, to XV, XVII, XXI, XXII, and XXVII showed a marked local anesthesic activity.