Studies on Diphenylmethane Derivatives. II. Synthesis of N-Substituted-1-(3, 4-dimethoxyphenyl)-1-(2-, 3- or 4-substituted phenyl) methylamine Derivatives

Abstract

N-Alkyl-1-(3, 4-dimethoxyphenyl)-1-(2-, 3-, or 4-substituted phenyl) methylamines (XI-XLVI) were synthesized from 3, 4-dimethoxybenzaldehyde and 2-, 3-, or 4-substituted bromobenzene using the Grignard reaction and halogenation, followed by amination with various alkylamines. Of the compounds synthesized and tested, XVIII was found to possess a weak antitussive activity, and XVI and XIX showed a marked local anesthesic activity.