1976 年 96 巻 11 号 p. 1298-1306
The effect of primary particle radius (γ0), addition of a polymer [po1y (vinylpyrrolidone), sodium carloxymethyl cellulose)], and centrifugal sedimentation on the sedimentation states of pyrimidine-penicillin G (PYG) were examined by the measurement of apparent aggregation degree (γm/γ0, where γm is the apparent secondary particle radius), porosity (ε) and tortuosity (q) of the sedimentation bed, and the amount of polymers adsorbed on particles. The following results were obtained. 1) γm/γ0 and ε did not change in parallel with each other while q and ε changed in the opposite direction with respect to the polymer concentration. 2) The effect of polymers on ε and difference in q with the direction of measurement were not found in the case of centrifugal sedimentation. 3) Saturated amount of adsorption X∞ of the polymers was higher than the theoretical value which was calculated by assuming monlayer adsorption of the monomers. 4) Plots of the data to see the relation between q and (1-ε) gave straight line. 5) qv/qH decreased with increase in ε at γ0= 1.8, 8.9, and 13.2 μmz, and almost constant against ε at 2.9 and 4.8 μm.