ヘッドスペースガスのガスクロマトグラフィーによる薬剤中のエタノールの簡易定量法(第1報)チンキ剤

抄録

A simple quantitative determination of ethanol in five samples of tinctures was attempted by gas chromatography using the head-space technique. The apparatus used were two models of gas chromatograph, one of which was equipped with a hydrogen flame ionization detector and the other with a thermal conductivity detector. Column packings were 5% polyethyleneglycol 20M (PEG 20M)/Chamelite or 5% Reoplex 400/Chromosorb in case of the former detector and 5% PEG 20 M/Chamelite in the latter. Gas chromatograms derived from the untreated tinctures did not present any peak except that of ethanol using the former detector, while low level signals of air and moisture were observed with the latter detector. When propanol was used as an internal standard, ethanol content in tinctures was capable of being calculated by Eq. (3). The results obtained resembled the values determined by the conventional three methods of JP 9, alcoholmeter, and dichromate oxidation.