Inhibitory Effect of Bis(2-hydroxybenzamido)benzoic Acid Derivatives on Reagin-mediated Passive Cutaneous Anaphylaxis (PCA) in Rats

Abstract

A new series of compounds, bis(2-hydroxybenzamido)benzoic acid derivatives, was examined for their inhibitory effect on homocytotropic reaginic antibody-mediated passive cutaneous anaphylaxis reaction in rats. When injected intravenously, 2, 4-bis(2-hydroxybenzamido)benzoic acid (AB-23) and 3, 5-bis(2-hydroxybenzamido)benzoic acid (AB-19) showed marked inhibition of this reaction. The inhibitory activity of the former was about three times stronger than that of the latter. When administered orally, 2, 4-bis(2-acetoxybenzamido)benzoic acid (AB-50), a diacetylated form of AB-23, was the most effective among all the compounds tested. The usefulness of AB-50 as an oral antiasthmatic drug was discussed.