Anti-tumor Activity of Compound Derived from Diketene and Their Related Compounds

Abstract

Various derivatives containing acetoacetamide, β-aminocrotonamide, pyrimidine, pyridine, dihydroxybenzoic acid, quinoline, pyridone, 2-pyrone and 2-pyrrolidone were prepared mainly from diketene. Their anti-tumor activities were examined by use of ascitic or solid type of Ehrlich carcinoma, and among them eleven compounds were found to have some anti-tumor effects on this solid tumor. These compounds were derivatives of pyrimidine (No. 30), pyridine (No. 41, 42, 54, 55, 56, 57 and 63), 2-pyrone (No. 124 and 125) and pyridopyrimidine (No. 137). No correlation was found between anti-tumor activity and these derivatives. No other substances in Table I-XII ; were effective.