Study on the Ingredients of Farfugium japonicum (L. f.) KITAMURA var. formosanum (HAY.) KITAMURA Structure of New Furanosesquiterpenes, Farformolide A and B

Abstract

Two new furanoeremophilenolides, farformolide A (IV) and farformolide B (V) in addition to three known terpenes (bakkenolide A (I), α-amyrin (II) and brein (III)) were isolated from the herbs of Farfugium japonicum (L. f.) KITAMURA var. formosanum (HAY.) KITAMURA (Ligularia tussilaginea BURM. var. formosana HAYATA) (Compositae) were isolated. Spectral investigation shows that these new sesquiterpenes, farformolide A and B should have the stereostructures of 3β-angeloyloxy-10β-hydroxyermophilenolide (IV) and 6β, 8β-dimethoxy-10β-hydroxyeremophilenolide (V), respectively.