ヘテロ環化合物の研究(第37報)Furo[3,2-c]pyrazole誘導体の合成 その5 α-Methyl-1-(p-substituted phenyl)-3-phenylfuro[3,2-c]pyrazole-5-acetic Acid類の合成

抄録

Examination of methods for the synthesis of α-methyl-1-(p-substituted phenyl)-3-phenylfuro [3, 2-c] pyrazole-5-acetic acid showed that the following route was found to be the most appropriate. 5-Benzoyl-2-furyl-α-methylacetonitrile is derived to methyl 5-benzoyl-α-methyl-2-furylacetate, which is oxidized with lead tetraacetate and boron trifluoride etherate, without isolation of the intermediate, followed by cyclization to methyl α-methyl-1, 3-diphenylfuro [3, 2-c] pyrazole-5-acetate which is hydrolyzed to the objective acid.