Studies on Pyridazinone Derivatives. VI. Reactions of 4, 5-Diethoxy-2-methyl (and phenyl)-3 (2H)-pyridazinones with Alkali and Acid

Abstract

Reactions of 4, 5-diethoxy-2-methyl (and phenyl)-3 (2H)-pyridazinone (I) with sodium ethoxide, 10% aqueous sodium hydroxide, and 47% hydrobromic acid were investigated. In some cases, the preferential displacement of 4-ethoxy group by hydroxyl group was observed, indicating that the displacement on the 3 (2H)-pyridazinone ring is affected by the nature of substituent at position 2, reaction species, and the medium enployed.