5,6,7,8,9,14-Hexahydrodibenz[d, g]azecine誘導体の合成

田中 照夫; 早坂 鐵太郎; 斎藤 圀朗; 成田 仙一

doi:10.1248/yakushi1947.98.5_649

Synthesis of 5, 6, 7, 8, 9, 14-Hexahydrodibenz [d, g] azecine Derivatives

TERUO TANAKA, TETSUTARO HAYASAKA, KUNIRO SAITO, SENICHI NARITA

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Keywords: dibenz [d, g] azecines, dibenzo [a, h] quinolizines, β-stimulant, catecholamine, O-demethylation, C-N bond cleavage

JOURNAL FREE ACCESS

1978 Volume 98 Issue 5 Pages 649-652

DOI https://doi.org/10.1248/yakushi1947.98.5_649

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Abstract

The reaction of 5, 6, 8, 9-tetrahydro-13bH-dibenzo [a, h] quinolizines with cyanogen bromide or ethyl chloroformate in the presence of magnesium oxide afforded a new ring system, 5, 6, 7, 8, 9, 14-hexahydrodibenz [d, g] azecines, in a good yield. By the application of this ring opening reaction, 2, 3, 11, 12-tetrahydroxy-5, 6, 7, 8, 9, 14-hexahydrodibenz [d, g]-azecine (5) was synthesized for pharmacological evaluation.

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