Distribution of 1-¹⁴C-Palmitic Acid and 1-¹⁴C-Myristic Acid on Their Oral Administration in Intact or Granuloma Pouch-Bearing Rats

Abstract

Comparative examinations were made on palmitic acid, which has an anti-inflammatory effect, and myristic acid, which has no such effect, for their incorporation into various tissues and body fluids in intact and granuloma pouch rats by oral administration of ¹⁴C-labeled fatty acids. In intact rats, significantly higher radioactivity was found in the heart, liver, spleen, and adrenals 2 hr after administration of 1-¹⁴C-palmitic acid, compared to that in the group given 1-¹⁴C-myristic acid. This trend continued for 24 hr. In granuloma pouch-bearing rats, radioactivity showed a significantly higher distribution in the adrenals and pouch exudate 2 hr after ¹⁴C-palmitic acid administration, compared to the group given myristic acid. This tendency continued for 24 hr. However, radioactivity in the pouch wall showed higher distribution in the rats given ¹⁴C-myristic acid.