Studies on the Syntheses of Heterocyclic Compounds. DCCLII. Cyclization Reaction of Amido-alcohols

Abstract

The acid catalyzed cyclization reaction with formaldehyde of the secondary amides possessing a hydroxyl group at α, β, or γ-position was attempted. New oxazolidinone derivatives (1 to 7), 1, 3-oxazinone derivatives (8 to 12), and 1, 3-oxazepinone derivatives (13 to 16) were obtained with the formation of 1, 3, 5-dioxazepinones (Va and Vb) as the by-product of 1 and 2, respectively.