Pyrazolo[3,4-d]pyrimidine誘導体に関する研究(第12報)1-Phenyl-1H-pyrazolo[3,4-d]pyrimidine-4-carboxylic Acidについて

抄録

1-Phenyl-1H-pyrazolo [3, 4-d] pyrimidine-4-carboxylic acid (I) forms an ester (III) with alcohols, in the presence of an acid. III reacts with hydroxylamine, hydrazine, and amines to form hydroxamic acid, hydrazide, and amides, respectively. I also forms a labile acid chloride (V) with thionyl chloride, and V reacts with alcohols, amines, and thioalcohols to form esters, amides, and thioesters, respectively. On the other hand, I easily undergoes decarboxylation to form 1-phenyl-1H-pyrazolo [3, 4-d] pyrimidine (VII). I undergoes the Hammick reaction, and decarboxylation by heating in the presence of a carbonyl compound affords a carbinol derivative (IX) or aryl 1-phenyl-1H-pyrazolo [3, 4-d]-pyrimidin-4-yl ketone (X) formed by oxidation of IX.