Abstract
Stabilization of the rat erythrocyte membrane by neuroleptic butyrophenones such as moperone, haloperidol, trifluperidol, clofluperol, floropipamide, and lenperone was examined. In low concentrations, all drugs used stabilized rat erythrocytes against hypotonic hemolysis, while at higher drug concentrations, the antihemolytic activities decreased along with increasing drug concentration. Clofluperol, the most potent neuroleptic of the drugs used, showed the highest antihemolytic activity and floropipamide, the least potent neuroleptic, showed the lowest. A good correlation was obtained between the partition coefficient (n-octanol/0.15 M phosphate buffer, pH 7.4) and antihemolytic activity of the drugs.
