Triazolo[4,5-d]pyrimidineに関する研究(第1報)7-Chloro-3-methyl-3H-1,2,3-triazolo[4,5-d]pyrimidineとNucleophileとの反応

抄録

Substitution reaction of 7-chloro-3-methyl-3H-1, 2, 3-triazolo [4, 5-d] pyrimidine (I) and nucleophiles was carried out and the formation of the corresponding 7-substituted 3-methyl-3H-1, 2, 3-triazolo [4, 5-d] pyrimidine (II) as expected was confirmed. I reacted with various amines to form the corresponding 7-amino derivatives (II-1 to II-8), and also reacted with alkoxide ions to form the corrrsponding 7-alkoxy compounds (II-9 to II-14). The reaction of I with CN ion in dimethylformamide, with ketone in the presence of sodium hydride, and with active methylene compounds resulted in the introduction of the corresponding carbon function into its 7-position. Tautomerism of 7-substituted 3-methyl-3H-1, 2, 3-triazolo [4, 5-d] pyrimidines (II-16 to II-24), formed by the reaction of I with ketones and active methylene compounds, was examined.