Acyloxyalkanoylcholine Derivatives. Synthesis and Contracting Activity on Smooth Muscle

Abstract

Acylated lactoylcholine derivatives were synthesized and their contracting activity on smooth muscle of isolated rat stomach, was examined by the Magnus method. Structure-activity relationship of these compounds was discussed. Acetyllactoylcholine, propionyllactoylcholine and butyryllactoylcholine were found to have strong activity.