1979 年 99 巻 2 号 p. 131-134
Twenty nine new compounds belonging to N-alkyl-3, 5-disubstituted pethidine derivatives were synthesized to investigate the relation between chemical structures and pharmacological activities. Analgesic activity of these compounds was examined by inhibitory action on writhing syndrome produced by 0.6% acetic acid in mice. In general, almost all the compounds, after administration of 50 mg/kg, were proved to have inhibitory action of more than 50 percent ; several of them (No. 11, 16, 26, 28, 29), had complete inhibitory action.