YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
ペチジン類似化合物の合成とその鎮痛作用について : Phenylglycidyl Ether誘導体の研究(第8報)
栗原 藤三郎武田 英重武田 秀雄菊地 正雄
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1979 年 99 巻 2 号 p. 131-134

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Twenty nine new compounds belonging to N-alkyl-3, 5-disubstituted pethidine derivatives were synthesized to investigate the relation between chemical structures and pharmacological activities. Analgesic activity of these compounds was examined by inhibitory action on writhing syndrome produced by 0.6% acetic acid in mice. In general, almost all the compounds, after administration of 50 mg/kg, were proved to have inhibitory action of more than 50 percent ; several of them (No. 11, 16, 26, 28, 29), had complete inhibitory action.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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