化学療法薬の合成(第2報)1,8-Naphthyridine誘導体の合成と抗トリコモナス活性
1979 年 99 巻 2 号 p. 155-164
詳細
1979 年 99 巻 2 号 p. 155-164
In order to find new antimicrobial agents, a number of substituted 1, 8-naphthyridine derivatives and related compounds were synthesized. Nitration of nalidixic acid with fuming sulfuric acid and fuming nitric acid gave 1-ethyl-1, 4-dihydro-3-nitro-4-oxo-1, 8-naphthyridine-7-carboxylic acid (30). Ethyl 7-substituted amino-1-ethyl-1, 4-dihydro-6-nitro-4-oxo-1, 8-naphthyridine-3-carboxylate (10b-d, g, h and m) obtained in this work showed nearly the same activity with metronidazole against Trichomonas vaginalis.
