An examination was made of the response of respiratory exchange ratio (R), carbon dioxide output (VCO
2) and oxygen uptake (VO
2) to sinusoidal work load with periods (T) of 1 - 16 min in six healthy men to determine whether R response is sinusoidal. The influence of the ratio of the amplitude of VCO
2 to that of VO
2 and the phase lag between them on R response was also studied by computer simulation. The results and conclusions obtained are as follows : 1 ) With decrease in the period, the amplitudes of VO
2 and VCO
2 dropped exponentially, becoming least at T of 1 min (T=1 min). In contrast, the amplitude of R was largest at T= 4 min and subsequently decreased progressively. 2 ) The peak amplitude of R at T=4 min can be explained by the larger phase lag and relatively low of amplitude of VCO
2 to VO
2. 3 ) The smallest amplitude of R at T = I min was due not to the ratio of amplitude or phase lag, but to remarkably smaller amplitudes of VO
2 and VCO
2. 4 ) The phase lag of VO
2 to sinusoidal work load was smaller than that of VCO
2. Phase lag of R was considerably larger than that of VO
2 or VCO
2 5 ) The response curve of VO
2 and VCO
2 is a sinusoidal curve with the same period as exercise. However, the response of R is not a real sinusoidal but a deformed biphasic curve with a high crest and low trough. The deformity is determined by the phase lag between VO
2 and VCO
2 response and also the ratio of amplitude of VCO
2 to that of VO
2.
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