Endocrine Journal
Our official Japanese journal "Naibunpigaku Zasshi" was first issued in 1925 and renamed as "Nihon Naibunpigaku-kai Zasshi" in 1927. In 1954 the first issue of English official journal "Endocrinologia Japonica" was published continuing to Volume 39 in 1992 and then renamed as the present "Endocrine Journal" from Volume 40 in 1993.

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Published by The Japan Endocrine Society  
6,837 registered articles
(updated on April 02, 2025)
Online ISSN : 1348-4540
Print ISSN : 0918-8959
ISSN-L : 0918-8959
1.9
2023 Journal Impact Factor (JIF)
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Featured article
Volume 72 (2025) Issue 4 Pages 341-353
Ghrelin–LEAP2 interactions along the stomach–liver axis Read more
Editor's pick

Recommendation from the Editor in Chief
There are examples where distinct two peptide ligands respectively act as an agonist and antagonist on the same receptor. To my knowledge, the best-known one is related with the story that alpha-MSH and agouti-related peptide (AgRP) act on the melanocrtin-4 receptor (MC4R) as an agonist and antagonist, thereby minutely regulating appetite and body weight. In this issue, Dr. Katsuya Sakai and Professor Masamitsu Nakazato, a world-renowned physician scientist on research of orexigenic hormone ghrelin, provide us with well-organized, fabulous review article focusing on the dynamic interaction between ghrelin and LEAP-2 (liver-expressed antimicrobial peptide 2) in terms of stomach-liver axis-driven appetite control. Indeed, ghrelin and LEAP-2 respectively act as an agonist and antagonist on the same receptor, GHSR (growth hormone secretagogue receptor). Our editorial team has a firm belief that all readers are surely motivated by the real deal of authentic endocrinology and cutting-edge medicine on GPCR signal transduction in this article.

Volume 72 (2025) Issue 3 Pages 259-272
Epidermal growth factor receptor contributes to indirect regulation of skeletal muscle mass by androgen Read more
Editor's pick

Recommendation from the Editor in Chief
Reflecting an expeditious increase in elder patients with sarcopenia notably in industrialized countries, endocrinologic research on molecular basis of muscle mass and strength has attracted great attention in both academic and clinical fields. In this issue, Dr. Tomoya Onishi, Professor Yuuki Imai and colleague provide fresh insight into unexpected interplay between androgens and epidermal growth factor receptor (EGFR) EGFR in the molecular pathophysiology of shrinkage of muscle mass. This excellent article provides all endocrinologists with updated viewpoint of sarcopenia science.

Volume 72 (2025) Issue 2 Pages 131-148
Role of radiologists in the diagnosis and management of adrenal disorders Read more
Editor's pick

Recommendation from the Editor in Chief
Radiographic diagnosis and therapeutic approach are requisite for clinics of endocrinology, especially for a series of adrenal diseases. From the unique standpoint of proficient radiologist, Dr. Oguro and colleague contribute a comprehensive and extensive review article focusing on this issue with a particular emphasis on segmental adrenal venous sampling (SAVS) and radiofrequency ablation for the treatment of unilateral primary aldosteronism (PA), shedding light on the importance of collaborative approach toward intractable endocrine diseases.

Volume 72 (2025) Issue 1 Pages 23-36
A narrative review of long-term inorganic iodine monotherapy for Graves’ disease with a historical relationship between iodine and thyroid Read more
Editor's pick

Recommendation from the Editor in Chief
It has been well recognized that inorganic iodine persistently suppresses thyroid function in some cases with Graves’ disease, and can be introduced as an alternative for patients with adverse events on antithyroid drugs. However, scientific bases are not fully elucidated and still remains empirical. In this issue, Dr. Natsuko Watanabe, an editorial board member of Endocrine Journal (EJ), contributes a well-organized, insightful narrative review focusing on this issue. The editorial team of EJ has a firm belief that all readers will be fascinated by an implicative “historical tale” around the relation between iodine and thyroid.

Volume 71 (2024) Issue 12 Pages 1103-1123
Osilodrostat treatment in patients with Cushing’s disease of Asian or non-Asian origin: a pooled analysis of two Phase III randomized trials (LINC 3 and LINC 4) Read more
Editor's pick

Recommendation from the Editor in Chief
Ethnicity-dependent differences in drug responsiveness have attracted broad attention also in endocrinological science. In this issue, Dr. Akira Shimatsu and Professor Beverly MK Biller at Massachusetts General Hospital, an active member of international honorary editors of Endocrine Journal, contribute an insightful original article focusing on ethnicity-related impact of oral 11beta-hydroxylase inhibitor, Osilodrostat between patients with Cushing’s disease of Asian and non-Asian origin. In comparison with non-Asians, Asian patients required apparently-lower doses of the drug to achieve clinical benefits, whereas adverse events related with hypocortisolism were manifested in Asians. As authors stated, this study is the first to compare the impact of drug therapy for patients with Cushing’s disease between Asian and non-Asian origin. Although ethnicity-dependent differences in bioavailability of the drug would be involved, elucidation of the entire picture is strongly anticipated.

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