Endocrine Journal
Online ISSN : 1348-4540
Print ISSN : 0918-8959
ISSN-L : 0918-8959
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39件中1~20件の論文を表示しています
  • 72 巻 (2025) 6 号 p. 649-662
    Hypopituitarism: genetic, developmental, and acquired etiologies with a focus on the emerging concept of autoimmune hypophysitis もっと読む
    編集者のコメント

    Recommendation from the Editor in Chief
    Amazing progress in research and clinics on molecular pathophysiology of hypopituitarism has recently attracted broad interest from endocrinologists. Particularly noteworthy is the great contribution of Japanese scientists to such an accomplishment. In the June issue, Dr. Hironori Bando and colleague at Kobe University provide us with cutting-edge, comprehensive review article on the update of hypopituitarism with a specific emphasis on paraneoplastic autoimmune hypopituitarism.

  • 72 巻 (2025) 5 号 p. 463-473
    Management of Cushing’s disease in the initial phase~From detection to surgery~ もっと読む
    編集者のコメント

    Recommendation from the Editor in Chief
    As well known, Cushing’s disease is a symbolic endocrine disorder in which a variety of basic, clinical, diagnostic and therapeutic insights are crystallized. Unexpectedly, however, there have still been unsolved issues in early diagnosis, interpretation for endocrinologic testing, and preoperative management. To better understand the latest situation around the clinics on Cushing’s disease, Dr. Hidenori Fukuoka seasonably provides a fascinating and comprehensive overview in the May Issue. Our editorial team has a firm belief that all readers will definitely be satisfied by the empirical knowledge of an expert endocrinologist.

  • 72 巻 (2025) 4 号 p. 341-353
    Ghrelin–LEAP2 interactions along the stomach–liver axis もっと読む
    編集者のコメント

    Recommendation from the Editor in Chief
    There are examples where distinct two peptide ligands respectively act as an agonist and antagonist on the same receptor. To my knowledge, the best-known one is related with the story that alpha-MSH and agouti-related peptide (AgRP) act on the melanocrtin-4 receptor (MC4R) as an agonist and antagonist, thereby minutely regulating appetite and body weight. In this issue, Dr. Katsuya Sakai and Professor Masamitsu Nakazato, a world-renowned physician scientist on research of orexigenic hormone ghrelin, provide us with well-organized, fabulous review article focusing on the dynamic interaction between ghrelin and LEAP-2 (liver-expressed antimicrobial peptide 2) in terms of stomach-liver axis-driven appetite control. Indeed, ghrelin and LEAP-2 respectively act as an agonist and antagonist on the same receptor, GHSR (growth hormone secretagogue receptor). Our editorial team has a firm belief that all readers are surely motivated by the real deal of authentic endocrinology and cutting-edge medicine on GPCR signal transduction in this article.

  • 72 巻 (2025) 3 号 p. 259-272
    Epidermal growth factor receptor contributes to indirect regulation of skeletal muscle mass by androgen もっと読む
    編集者のコメント

    Recommendation from the Editor in Chief
    Reflecting an expeditious increase in elder patients with sarcopenia notably in industrialized countries, endocrinologic research on molecular basis of muscle mass and strength has attracted great attention in both academic and clinical fields. In this issue, Dr. Tomoya Onishi, Professor Yuuki Imai and colleague provide fresh insight into unexpected interplay between androgens and epidermal growth factor receptor (EGFR) EGFR in the molecular pathophysiology of shrinkage of muscle mass. This excellent article provides all endocrinologists with updated viewpoint of sarcopenia science.

  • 72 巻 (2025) 2 号 p. 131-148
    Role of radiologists in the diagnosis and management of adrenal disorders もっと読む
    編集者のコメント

    Recommendation from the Editor in Chief
    Radiographic diagnosis and therapeutic approach are requisite for clinics of endocrinology, especially for a series of adrenal diseases. From the unique standpoint of proficient radiologist, Dr. Oguro and colleague contribute a comprehensive and extensive review article focusing on this issue with a particular emphasis on segmental adrenal venous sampling (SAVS) and radiofrequency ablation for the treatment of unilateral primary aldosteronism (PA), shedding light on the importance of collaborative approach toward intractable endocrine diseases.

  • 72 巻 (2025) 1 号 p. 23-36
    A narrative review of long-term inorganic iodine monotherapy for Graves’ disease with a historical relationship between iodine and thyroid もっと読む
    編集者のコメント

    Recommendation from the Editor in Chief
    It has been well recognized that inorganic iodine persistently suppresses thyroid function in some cases with Graves’ disease, and can be introduced as an alternative for patients with adverse events on antithyroid drugs. However, scientific bases are not fully elucidated and still remains empirical. In this issue, Dr. Natsuko Watanabe, an editorial board member of Endocrine Journal (EJ), contributes a well-organized, insightful narrative review focusing on this issue. The editorial team of EJ has a firm belief that all readers will be fascinated by an implicative “historical tale” around the relation between iodine and thyroid.

  • 71 巻 (2024) 12 号 p. 1103-1123
    Osilodrostat treatment in patients with Cushing’s disease of Asian or non-Asian origin: a pooled analysis of two Phase III randomized trials (LINC 3 and LINC 4) もっと読む
    編集者のコメント

    Recommendation from the Editor in Chief
    Ethnicity-dependent differences in drug responsiveness have attracted broad attention also in endocrinological science. In this issue, Dr. Akira Shimatsu and Professor Beverly MK Biller at Massachusetts General Hospital, an active member of international honorary editors of Endocrine Journal, contribute an insightful original article focusing on ethnicity-related impact of oral 11beta-hydroxylase inhibitor, Osilodrostat between patients with Cushing’s disease of Asian and non-Asian origin. In comparison with non-Asians, Asian patients required apparently-lower doses of the drug to achieve clinical benefits, whereas adverse events related with hypocortisolism were manifested in Asians. As authors stated, this study is the first to compare the impact of drug therapy for patients with Cushing’s disease between Asian and non-Asian origin. Although ethnicity-dependent differences in bioavailability of the drug would be involved, elucidation of the entire picture is strongly anticipated.

  • 71 巻 (2024) 11 号 p. 1093-1096
    Snap diagnosis of fulminant type 1 diabetes by the normalized glucose/HbA1c ratio もっと読む
    編集者のコメント

    Recommendation from the Editor in Chief
    It is well recognized that patients with fulminant type 1 diabetes (FT1D), originally characterized by Professor Imagawa and Hanafusa et al, require expeditious diagnosis and successive intensive care. Inspired by the notion that incidence of FT1D in Caucasians has been extremely rare as compared to Asians, Dr. Mori and colleague propose the index beneficial for the snap diagnosis of FT1D in the November issue. Such a valuable suggestion is strongly anticipated to save lives of previously-undiagnosed FT1D worldwide.

  • 71 巻 (2024) 10 号 p. 1003-1011
    Cushing’s disease with twin pregnancy and diabetes mellitus: a case report and literature review もっと読む
    編集者のコメント

    Recommendation from the Editor in Chief
    Dr. Hideyasu Asai and colleague report in the October issue an extremely rare case of a pregnant woman with twins suffering from Cushing’s disease, exemplifying hypercortisolism, hypothyroidism and diabetes. After the successful spontaneous vaginal delivery, she received a transsphenoidal surgery, resulting in partial mitigation of hypercortisolism and complete normalization of thyroid function, possibly via the cancellation of cortisol-driven suppression of TSH as well as conversion of T4 to T3. This in-depth case report on a rare situation coupled with pregnancy and hyper ACTH in circulation provides us with fresh insight into elaboration of endocrine networks throughout the body.

  • 71 巻 (2024) 9 号 p. 827-837
    Biological roles of growth hormone/prolactin from an evolutionary perspective もっと読む
    編集者のコメント

    Recommendation from the Editor in Chief
    It is well known that growth hormone (GH) and prolactin (PRL) share a series of close similarities in molecular developmental, structural, intracellular signaling, physiological and pathophysiological aspects. In the September issue, Professor Yasumasa Iwasaki, one of the Japan’s proud scholars in endocrinologic science, provides us with truly fabulous review article particularly focusing on the unique profile of GH and PRL as “metabo”kines with a perspective of evolutionary endocrinology. Our editorial team has a firm belief that all readers will definitely be fascinated and moved by the full of academic incense contained.

  • 71 巻 (2024) 8 号 p. 745-751
    Epithelial mesenchymal transition in human menstruation and implantation もっと読む
    編集者のコメント

    Recommendation from the Editor in Chief
    To further enhance the success rate of fertility therapy, it is critical to understand the elaborate molecular mechanisms for regeneration of endometrium, which are extremely unique regenerative tissue in human body. In the August issue, Dr. Hiroshi Uchida provides us with an exciting review particularly focused on the endocrinologic comparison between epithelial to mesenchymal transition (EMT) in common wound healing and endometrial tissue remodeling in the sexual cycle. This excellent article provides all endocrinologists with invaluable and updated insight into menstruation and implantation in humans.

  • 71 巻 (2024) 7 号 p. 643-650
    Promising horizons in achondroplasia along with the development of new drugs もっと読む
    編集者のコメント

    Recommendation from the Editor in Chief
    Achondroplasia (ACH) has long been an extremely intractable disease in children characterized by both rhizomelic shortened limbs and considerable shot stature. In the July issue, a world-renowned endocrinologist, Dr. Keiichi Ozono and colleague provide an inspirational and cutting-edge review on the update of molecular mechanisms and brand-new therapeutic modalities for ACH. Our editorial team has a firm belief that such a “making the impossible possible” story in the translational research of endocrinology is a must-read for all readers in Endocrine Journal.

  • 71 巻 (2024) 6 号 p. 547-559
    Development of the anterior pituitary: diverse lineages of the stem/progenitor cells もっと読む
    編集者のコメント

    Recommendation from the Editor in Chief
    As well known, the pituitary gland is composed of two distinct parts originated from both adenohypophyseal placode and neuroectoderm. For most of endocrinologists, however, not much is known about the recent research progress in this field. Dr Yukio Kato and Dr Takako Kato seasonably provide a fascinating and updated overview on the molecular development of pituitary gland with a cutting-edge insight into cellular and endocrinologic mechanisms.

  • 71 巻 (2024) 5 号 p. 437-445
    Cell-specific functions of androgen receptor in skeletal muscles もっと読む
    編集者のコメント

    Recommendation from the Editor in Chief
    It is widely recognized that androgens play a crucial role not only in developing secondary sexual characteristics in men but in exerting protein anabolic effects as anabolic steroids. In this issue, Professor Yuuki Imai and Dr. Hiroshi Sakai contribute a sophisticated and insightful review on cell-specific functions of androgen receptor within skeletal muscles, particularly in satellite cells, myofibers and mesenchymal progenitors. A variety of indirect effects of androgens via extra-muscle tissue on skeletal muscle are also impressively highlighted.

  • 71 巻 (2024) 4 号 p. 335-343
    Phosphate-sensing mechanisms and functions of phosphate as a first messenger もっと読む
    編集者のコメント

    Recommendation from the Editor in Chief
    Fibroblast growth factor 23 (FGF23) plays a critical role in regulating circulating phosphate level. To date, however, mechanisms whereby bone senses the change of blood phosphate level and regulates the production of FGF23 have been poorly elucidated. In this issue, Dr. Yuichi Takashi contributes an insightful review article focusing on such long-lasting enigmas. Our editorial team is sure that readers will be fascinated by the profound world of phosphate homeostasis via unique endocrine systems.

  • 71 巻 (2024) 3 号 p. 295-303
    Lung adenocarcinoma metastasis within a pituitary neuroendocrine tumor: a case report with review of literature もっと読む
    編集者のコメント

    Recommendation from the Editor in Chief
    Dr. Koji Suzuki and colleague report in the March issue an extremely rare case of metastatic lung adenocarcinoma within a gonadotroph pituitary neuroendocrine tumor (PitNET), representing a considerably expeditious progression of a variety of neurological symptoms. This excellent report provides us with invaluable insight into diagnosis and therapeutics for coexisting primary and metastatic tumors in pituitary gland.

  • 71 巻 (2024) 2 号 p. 101-118
    Single-cell and spatial transcriptomics in endocrine research もっと読む
    編集者のコメント

    Recommendation from the Editor in Chief
    As well known, endocrine organs including pituitary gland, adrenal gland and pancreatic islet of Langerhans et cetera consist of heterogenous cells, and pathophysiological interplay among hormone-producing cells and non-hormone-producing cells within tissue is crucial, at least in part, for molecular basis of a variety of endocrine diseases. In the February issue, Dr. Ryusaku Matsumoto and Takuya Yamamoto provide a comprehensive, fascinating review article focusing on the update of single-cell and spatial transcriptomics in endocrine research. Our editorial team has a firm belief that this review is a must-read for all dedicating clinicians and scientists on endocrinology.

  • 71 巻 (2024) 1 号 p. 23-29
    Clinical characteristics and potential biomarkers of thyroid and pituitary immune-related adverse events もっと読む
    編集者のコメント

    Recommendation from the Editor in Chief
    It is widely recognized that some cases of immune-related adverse events (irAEs) caused by immune checkpoint inhibitors (ICIs) result in life-threatening consequences including adrenal crisis and fatal diabetic ketoacidosis. In this issue, Dr. Tomoko Kobayashi and colleague contribute an insightful and well-organized review article on promising biomarkers to predict the onset of endocrine irAEs, particularly underscoring the mechanism-based management strategies and future prospect for pituitary and thyroid irAEs.

  • 70 巻 (2023) 12 号 p. 1123-1130
    Relationship between Ca2+ and cAMP as second messengers in ACTH-induced cortisol production in bovine adrenal fasciculata cells もっと読む
    編集者のコメント

    Recommendation from the Editor in Chief
    It is well known that both Ca2+ and cAMP play critical roles in ACTH-driven cortisol production by adrenal fasciculate cells. However, the division of role for Ca2+ and cAMP in this paradigm still remains obscure. In the December Issue, Dr. Masahiko Kutsukake and colleague elegantly unraveled such a long-standing enigma via sophisticated cellular experiments, demonstrating that cortisol production under steady state is preferentially mediated by Ca2+, but cAMP also participates under stressful conditions where ACTH demand is increased to adapt exaggerated stress.

  • 70 巻 (2023) 10 号 p. 987-998
    Prediction-based prompt levothyroxine replacement to prevent a hypothyroid state after immune-related adverse events involving the thyroid gland もっと読む
    編集者のコメント

    Recommendation from the Editor in Chief
    As well known, immune checkpoint inhibitors (ICIs) sometimes cause immune-related adverse events in the thyroid gland (thyroid irAEs). Dr. Ichiro Yamauchi and colleague conducted an elaborate retrospective cohort study demonstrating that patients with rapid-onset severe thyrotoxicosis as well as with positive TgAbs titers were highly likely to develop subsequent hypothyroidism. This study provides us with a message that expeditious replacement of levothyroxine is a crucial precaution against severely hypothyroid state.

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