Endocrine Journal
Online ISSN : 1348-4540
Print ISSN : 0918-8959
ISSN-L : 0918-8959
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  • 69 巻 (2022) 8 号 p. 881-896
    Advances in understanding of phosphate homeostasis and related disorders もっと読む
    編集者のコメント

    Science and clinics on phosphate homeostasis are no doubt an authentic, royal road to endocrinology. As most of readers of Endocrine Journal well recognize, basic scientists and endocrinologists in Japan have made a huge contribution to the molecular medicine on fibroblast growth factor 23 (FGF 23) in this academic field. To STATE-OF-THE-ART REVIEW IN ENDOCRINOLOGY in this issue, Dr. Michigami contributes an extensive, well-organized article on the recent research progress in phosphate homeostasis and related disorders with a particular emphasis on FGF 23, providing us with an invaluable perspective for cutting-edge area of bone-mineral endocrinology.

  • 69 巻 (2022) 7 号 p. 739-748
    New perspectives on obesity-induced adipose tissue fibrosis and related clinical manifestations もっと読む
    編集者のコメント

    Dynamic remodeling of adipose tissue plays a critical role in the pathophysiology of obesity disease. In this article, Dr. Yutaka Hasegawa elegantly updates the research on the molecular mechanism whereby adipocytes interact with non-adipocytes during the course of adipose dysfunction and fibrosis in obesity. This review does provide us with invaluable perspective for endocrinology-based obesity science.

  • 69 巻 (2022) 6 号 p. 689-703
    Effects of a new 75 g glucose- and high fat-containing cookie meal test on postprandial glucose and triglyceride excursions in morbidly obese patients もっと読む
    編集者のコメント

    It has been highlighted that postprandial hyperinsulinemia-associated hypoglycemia sometimes happens in patients with morbid obesity after metabolic surgeries. In the present study, Dr. Yukako Yamamoto and her colleague provide a line of convincing data demonstrating that a 75 g glucose- and high fat-containing cookie meal test is useful in severely obese subjects to precisely evaluate glucose intolerance and postprandial dyslipidemia without occurrence of hyperinsulinemia-associated hypoglycemia. The cookie meal test may open a fresh avenue to conveniently monitor fuel homeostasis in the course of multidisciplinary therapies for obese-diabetic patients.

  • 69 巻 (2022) 5 号 p. 547-557
    Low plasma renin activity is independently associated with kidney disease progression in patients with type 2 diabetes and overt nephropathy, including those with impaired kidney function: a 2-year prospective study もっと読む
    編集者のコメント

    A variety of factors including dysregulation of renin-angiotensin-aldosterone system in both systemically and locally are well known to affect the progression of diabetic nephropathy (DN).To our surprise, however, the possible association between the plasma renin activity (PRA) and renal outcomes in patients with DN still remains obscure. In the present article, Dr. Kazuyoshi Kuma and colleague elegantly addressed such a unsolved question in a 2 year-prospective study, highlighting that low in PRA is an independent risk for the progression of DN in a Japanese cohort.

  • 69 巻 (2022) 4 号 p. 373-383
    Burden of disease of X-linked hypophosphatemia in Japanese and Korean patients: a cross-sectional survey もっと読む
    編集者のコメント

    X-linked hypophosphatemia (XLH) in known to substantially secrete FGF23, thereby causing renal phosphate loss, chronic hypophosphatemia and a variety of involvement in skeletal system. However, the reality in clinics has not been fully examined. In the present study, via the online questionnaire methods, Ito N et al. comprehensively evaluate the current status and health-related quality of life in patients with XLH living in Japan and Korea, providing us with the latest knowledge and insight into XHL.

  • 69 巻 (2022) 3 号 p. 319-326
    DNA methylation level of the gene encoding thioredoxin-interacting protein in peripheral blood cells is associated with metabolic syndrome in the Japanese general population もっと読む
    編集者のコメント

    Convincing and conveniently-evaluated molecular biomarkers for prediction and assessment of metabolic syndrome are warranted to realize precision health as well as precision medicine in lifestyle-related diseases. In the present study, Yamazaki M and colleague provide intriguing evidence that level of DNA methylation of the gene encoding thioredoxin-interacting protein, a key inhibitor of cellular oxidation, is significantly decreased in peripheral blood cells from subjects with metabolic syndrome. Further extensive studies are strongly expected to see whether such a status of hypomethylation is clinically relevant to the extent of systemic oxidative stress and would be reversible in response to a line of lifestyle modifications or metabolic surgeries.

  • 69 巻 (2022) 2 号 p. 139-154
    Pathological diagnosis of general rules for the description of thyroid cancer by Japanese Society of Thyroid Pathology and Japan Association of Endocrine Surgery もっと読む
    編集者のコメント

    In this issue, Kamma H and colleague highlight the update of general rules for the description of thyroid cancer proposed by Japanese Society of Thyroid Pathology and Japan Association of Endocrine Surgery. This article is strongly expected to lay a brand-new cornerstone in transferring Japanese diagnostic standard on thyroid cancer for the world.

  • 69 巻 (2022) 1 号 p. 95-100
    A case of central diabetes insipidus due to neurophysin II gene abnormality diagnosed based on a family history of nocturnal enuresis もっと読む
    編集者のコメント

    In this issue, Sugawara L and colleague provide a line of convincing results of genetic analyses on neurophysin II (NPII) in a pedigree of neurohypophyseal diabetes insipidus.

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