Background: Patients undergoing hyperbaric oxygen (HBO2) treatment often report changes in sleep. We conducted an uncontrolled pilot study of subjective sleep scales and sleep parameters measured using actigraphy. Methods: Fifteen patients (3 male and 12 female) referred for HBO2 treatment of their underlying illnesses were recruited for this study. Sleep quality indices were determined applying the Japanese version of the Pittsburgh Sleep Quality Index (PSQI-J), the Epworth Sleepiness Scale (JESS), the Visual Analog Scale (VAS), and actigraphy. All 15 subjects were tested before HBO2 treatment and after no more than five (mean 2.7) treatments. Nine subjects were further tested after at least 20 (mean 26) treatments. Results: After no more than five HBO2 treatments, there were overall improvements in sleep indices indicated by reductions in the PSQI-J total score and shorter sleep onset latency, which was consistent with the actigraphy data. After at least 20 HBO2 treatments, there were improvements in the PSQI-J total score and in the sleep quality and daytime dysfunctions subscales, as well as in the JESS total score. For the VAS, there was an improvement in fatigue after no more than five HBO2 treatments and after at least 20 HBO2 treatments. Original symptoms improved after at least 20 treatments, but not after no more than five treatments. Conclusion: The shorter sleep onset latency appears to be an immediate effect of HBO2 treatment since this change occurred prior to the alleviation of original symptoms, mainly pain. HBO2 could potentially be applied for the treatment for patients with sleep disorders or athletes suffering from jet lag due to international travel.
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