Muir-Torre syndrome, a rare hereditary autosomal dominant cancer syndrome, is characterized by a predisposition to cancers of the colon and genitourinary tract, as well as skin lesions such as keratoacanthomas and sebaceous tumors. Herein, we report a case of an 87-year-old man with a history of colon cancer, who presented with an extraocular sebaceous carcinoma on the face in close proximity to his ear. We suspected Muir-Torre syndrome. We resected the tumor and histopathological examination of the resected specimen confirmed the presence of sebaceous carcinoma, squamous cell carcinoma, and basal cell carcinoma. We report a unique case of concomitant development of three types of malignant skin lesions at the same site. To our knowledge, this is the first report of this extremely rare condition.
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