Changes in temperature influence cardiac lusitropic function, and hypothermia prolongs the relaxation process and hyperthermia shortens it. The goodness of halflogistic (hL) function curve-fits for the isovolumic relaxation left ventricular (LV) curves from the minimum of the first time derivative of LV pressure (d
P/d
tmin) observed at different temperatures are superior to the goodness of conventional mono-exponential (mE) function curve-fits, as the correlation coefficients are larger and residual mean squares are smaller for hL functions than mE functions at any temperature. The hL time constant (
PτL) is dependent on temperature as is the mE time constant (
PτE), and PτL could be a more precise lusitropic index than
PτE.
PτE is overestimated in hypothermia and underestimated in hyperthermia. It is suggested that
PτL decays with increasing temperature and decreasing d
P/d
tmin as is characteristics of the hL function curve. The temperature coefficient (
Q10) value of the reciprocal of
PτL is 2.2. The hL function is a more useful model than the mE function for evaluating lusitropism of the isovolumic relaxation LV curve and
PτL is a more reliable relaxation time constant than
PτE regardless of temperature.
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