A 74-year-old woman visited our hospital for consultation for a liver mass that was found during treatment at another hospital for alcoholic hepatitis and cirrhosis. Two subtypes of hepatocellular carcinomas (HCCs) were found: S2 and S4 HCCs that were 13 and 10 mm in size, respectively. A radiofrequency ablation was performed for the S4 HCC. Furthermore, the S2 HCC was treated via a laparoscopic partial liver resection. The range of the tumor was confirmed by ultrasonography, a site 10 mm from the tumor was used as the planned dissection line, and ablation was performed at an interval of 1 cm with 55 W for 30 seconds using Microtase. The liver was dissected and a partial hepatic resection was performed for the S2 HCC. The patient was discharged on postoperative day six without any obvious postoperative complications. After 14 months, the postoperative course has been uneventful with no recurrence noted. The use of Microtase in a patient who underwent laparoscopic liver resection suggests that it may be sufficient to control hemorrhages in cases of liver cirrhosis such as in the present case.