Retinal prosthesis is a medical device designed to restore vision in patients who have lost sight due to photoreceptor degenerative disorders, such as retinitis pigmentosa, by electrically stimulating the remaining retinal neurons. Three major approaches—epiretinal, subretinal, and suprachoroidal implantation—have been developed, each with unique technical advantages and limitations. Clinical studies of devices such as the ARGUS II, Alpha IMS/AMS, PRIMA, and suprachoroidal-transretinal stimulation have demonstrated partial recovery of visual functions and modest improvements in daily activities. However, the level of vision achieved remains significantly below that of natural sight. This review summarizes recent advances in retinal prosthesis research, highlights clinical study outcomes, and discusses future prospects.

This paper discusses Electroretinogram (ERG) in cynomolgus monkeys used in non-clinical study. ERG involves stimulating the retina with light, and recording the resultant response as waveforms, thereby assessing retinal function. The retinal structure of cynomolgus monkeys closely resembles that of humans, making ERG data from cynomolgus monkeys highly contributory to the development of new pharmaceuticals and treatment methods. This article provides detailed descriptions of the measurement methods, waveform specifics, and responses based on the ISCEV standard, in addition to addressing important considerations during measurement. It is hoped that this paper will aid in advancing ERG research utilizing cynomolgus monkeys.