Background: Few data on multidrug-resistant organisms (MDROs) and educational intervention to improve the antimicrobial use in Japanese long-term-care hospitals have been reported.
Method: This study reports the current epidemiology on MDROs in a long-term-care hospital. Also, we performed a multifaceted educational intervention on antimicrobial stewardship and retrospectively compared several quality control indexes, such as appropriate antibiotic use, prevalence of MDROs, blood culture, and therapeutic drug monitoring, of clinical practice on infectious diseases before and after the intervention. The baseline and intervention periods were from April through September 2015 and from April through September 2016, respectively. The intervention included bed-side consultations with emphasis on gram staining, institutional lectures with didactic educational materials, producing annual cumulative antibiogram, and so on.
Results: The antimicrobial use density of cefmetazole increased 2.2 times, whereas that of meropenem and levofloxacin decreased by 30% and 46%, respectively. The fluoroquinolone resistance of Escherichia coli and the proportion of extended-spectrum beta-lactamase (ESBL)-producing E. coli before and after the intervention were 71% and 65% and 68% and 68%, respectively. The number of blood cultures per 1000 hospital admissions before and after the intervention were 281 and 859, respectively.
Conclusions: Our data revealed that ESBL-producing E. coli was extensively prevalent. Also, the use of broad-spectrum antibiotic decreased, which could be due to the regular institutional lectures where all physicians attended and shared relevant information efficiently. In addition, gram staining may have contributed to the reduction of broad-spectrum antibiotic use because physicians could estimate causative organisms and use narrower-spectrum antibiotics as an empiric therapy.
View full abstract