(Purpose)
We examined the factors that cause mild cognitive decline (MCI) to develop dementia after a long course.
(Case and Method)
In the same case, there are 10 normal cases with less than 10 points at the time of initial diagnosis and 23
MCIs between 10 and 16.6 points in ADASJ that are more than 3 years.
Hippocampal atrophy (+) was a VSRAD-Z value of 2.0 or more or -Ratio of 5 times or more, cerebral ischemia (+) was a case of periventricular or deep subcortical white matter lesions of grade 3 or higher, and cerebral blood flow reduction was a case of two or more outliers in the disease specific area analysis
(SVA) 3 index.
Cognitive function items were classified into four categories of memory, orientation, language, and act, and were evaluated by the ratio of each total score, and factors that resulted in dementia (16.6 or higher in ADASJ) were examined.
(Result)
Dementia was not involved in the presence or absence of hippocampal atrophy, ischemic changes, and decreased cerebral blood flow, and was common in inactive life cases, significantly reducing orientation function.
(Conclusion)
Although it was suggested that active life improves disorientation function as a measure to prevent the progression of cognitive impairment in cases with normal and MCI levels at the time of initial diagnosis, further intervention studies are needed to determine whether inactive life conditions contribute to the progression of cognitive impairment or as a result of the progression of cognitive impairment.
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