Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics

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21st JSSX Annual Meeting

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Short Oral Presentations

FXR AND LXR ALPHA REGULATE THE INDUCIBLE EXPRESSION OF MOUSE ORGANIC SOLUTE TRANSPORTER ALPHA/BETA

Tappei Takada, Masae Okuwaki, Hiroshi Suzuki

Session ID: 01B11-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.246.1

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PPARα REGULATES SLCO1B1 GENE TRANSCRIPTION IN HUMAN LIVER IN COOPERATION WITH HEPATOCYTE NUCLEAR FACTOR-1α

Tomomi Furihata, Naoko Yamamoto, Tomomi Satoh, Kan Chiba

Session ID: 01B11-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_246_2

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INVOLVEMENT OF A CALCIUM/CALMODULIN MEDIATED PATHWAY IN THE REGULATION OF THE TRANSPORT ACTIVITY OF ESTRONE-3-SULFATE IN CACO-2 CELLS

Shuhei Takano, Megumi Uchida, Tomoo Itoh

Session ID: 01B11-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.247.1

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REGULATION OF OATP2B1 (OATP-B) ACTIVITY BY SIGNAL TRANSDUCTION PATHWAYS

Megumi Uchida, Shuhei Takano, Tomoo Itoh

Session ID: 01B11-4
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_247_2

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INVESTIGATION OF THE INHIBITORY EFFECTS OF VARIOUS THERAPEUTIC DRUGS ON OATP1B3-MEDIATED UPTAKE OF FEXOFENADINE

Soichiro Matsushima, Kazuya Maeda, Yuichi Sugiyama

Session ID: 01C09-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.248.1

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CEFTRIAXONE IS A POTENT SUBSTRATE OF HUMAN MRP4 AND ITS TRANSPORT IS INHIBITED BY VANCOMYCIN, FUROSEMIDE, BUMETANIDE AND ETHACRYNIC ACID

Xiao-Kun Cai, Yasuo Uchida, Junichi Kamiie, Sumio Ohtsuki, Tetsuya Ter ...

Session ID: 01C09-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_248_2

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INVESTIGATION OF THE INVOLVEMENT OF TRANSPORTERS IN THE HEPATIC TRANSPORT OF KP-496, A NEW DUAL ANTAGONIST OF LEUKOTRIENE D₄ AND THROMBOXANE A₂ RECEPTORS

Akinori Aoyama, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama

Session ID: 01C09-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.249.1

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INVESTIGATION OF THE BILIARY EXCRETION MECHANISM OF FLUOROQUINOLONES IN MICE

Tomohiro Ando, Hiroyuki Kusuhara, Gracia Merino, Alfred H. Schinkel, Y ...

Session ID: 01C10-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_249_2

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MECHANISM OF MOLECULAR WEIGHT THRESHOLD IN BILIBARY EXCRETION OF β-LACTAM ANTIBIOTICS

Seiko Takahara, Yoshiyuki Kubo, Yukio Kato, Akira Tsuji

Session ID: 01C10-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.250.1

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STUDIES OF THE TRANSPORT MECHANISMS OF OLMESARTAN IN LIVER AND KIDNEY

Akihiro Yamada, Kazuya Maeda, Yuichi Sugiyama

Session ID: 01C10-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_250_2

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INVOLVEMENT OF OATP FAMILY TRANSPORTERS IN THE HEPATIC UPTAKE OF BOSENTAN

Kazuya Kubo, Kazuya Maeda, Yuichi Sugiyama

Session ID: 01C10-4
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.251.1

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INVOLVEMENT OF CREATINE TRANSPORTER AT THE BLOOD-CEREBROSPINAL FLUID BARRIER IN THE ELIMINATION OF GUANIDINOACETATE FROM THE CEREBROSPINAL FLUID.

Masanori Tachikawa, Jun Fujinawa, Toshihisa Nakashima, Masatoshi Tomi, ...

Session ID: 01C10-5
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_251_2

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RENAL TRANSPORT MECHANISMS OF EDARAVONE AND ITS CONJUGATED METABOLITES.

Naomi Mizuno, Tsuyoshi Takahashi, Hiroyuki Kusuhara, Takuro Niwa, Yuic ...

Session ID: 01C11-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.252.1

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ROLE OF P-GLYCOPROTEIN (P-GP), BREAST CANCER RESISTANT PROTEIN (BCRP) AND ORGANIC CATION TRANSPORTER 1 (OCT1) IN ACQUIRED RESISTANCE TO IMATINIB IN K562 CELLS.

Chie Hirayama, Reiko Nakashima, Takeru Nanbu, Hiroshi Watanabe, Akinob ...

Session ID: 01C11-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_252_2

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Absorption properties of vinblastine, a P-glycoprotein substrate, from various administration routes

Satoyo Nishikawa, Akira Yamamoto, Takuo Ogihara, Takuya Fujita

Session ID: 01C11-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.253.1

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REGIONAL DIFFERENCE IN MEMBRANE PERMEABILITY OF METHYLPREDNISOLONE THROUGH EFFLUX TRANSPORTER IN RAT

Atsuko Watanabe, Mikio Tomita, Masahiro Hayashi

Session ID: 01C11-4
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_253_2

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Drug-induced lung toxicity caused by the inhibition of choline uptake transporter in human lung adenocarcinoma A549 cells

Naoki Ishiguro, Masanobu Oyabu, Toshihiro Sato, Tomoji Maeda, Hironobu ...

Session ID: 01D09-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.254.1

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CHOLESTEROL LOWERING EFFECT OF EZETIMIBE IN UDP-GLUCURONYLTRANSFERASE (UGT) 1A DEFICIENT (GUNN) RATS

Takehito Yamamoto, Kousei Ito, Masashi Honma, Tappei Takada, Hiroshi S ...

Session ID: 01D09-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_254_2

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Metabolism of carbamate pesticides by liver microsomes and plasma of rats and humans, and its effect on endocrine-disrupting activity

Satoko Tange, Shigeyuki Kitamura, Nariaki Fujimoto, Kazumi Sugihara, S ...

Session ID: 01D09-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.255.1

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DIFFERENCES IN RENAL ACCUMULATION AND SUBSEQUENT NEPHROPATHY AMONG FOUR PLATINUM AGENTS IN RATS

Sachiko Yokoo, Atsushi Yonezawa, Satohiro Masuda, Toshiya Katsura, Ken ...

Session ID: 01D10-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_255_2

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TUBULAR EXPRESSION OF TRANSPORTERS AND SECRETION OF CATIONIC DRUGS IN 5/6 NEPHRECTOMIZED FEMALE RATS

Kumiko Nishihara, Lin Ji, Satohiro Masuda, Toshiya Katsura, Ken-ichi I ...

Session ID: 01D10-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.256.1

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SUPPRESSION OF DRUG -INDUCED LIVER INJURY IN RATS FED A HIGH-FAT AND HIGHSUCROSE DIETT BY DIETARY INULIN IS ASSOCIATED WITH THE REDUCTION IN HEPATIC CYTOCHROME P450 AND HEPATOCYTE NUCLEAR FACTOR 4α EXPRESSION

Makoto Osabe, Junko Sugatani, Tadashi Wada, Kouichi Yoshinari, Tadanob ...

Session ID: 01D10-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_256_2

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ACTIVATION OF P53 AS A CAUSE OF ATHEROSCLEROSIS INDUCED BY POLYCYCLIC AROMATIC HYDROCARBONS

Shunsuke Iwano, Norihito Shibahara, Tetsuya Saito, Tetsuya Kamataki

Session ID: 01D10-4
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.257.1

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34CYS OF HUMAN SERUM ALBUMIN IS AN IMPORTANT RESIDUE FOR OXIDATIVE STRESS ON HEMODIALYSIS PATIENTS

Koji Takeuchi, Makoto Anraku, Kenichiro Kitamura, Toru Maruyama, Masak ...

Session ID: 01D10-5
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_257_2

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PREVENTIVE EFFECTS OF BICARBONATE ON STATIN-INDUCED MUSCLE DAMAGE

Masaki Kobayashi, Toshiki Kagawa, Fumie Kaido, Shirou Itagaki, Takeshi ...

Session ID: 01D11-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.258.1

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ASSESSMENT OF ANTIOXIDATIVE EFFCTS OF SUPPLEMENT COMPONENTS

Toshimitsu Kurokawa, Masaki Kobayashi, Shirou Itagaki, Takeshi Hirano, ...

Session ID: 01D11-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_258_2

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INTESTINAL ABSORPTION AND DISPOSITION OF P-GLYCOPROTEIN SUBSTRATE AFTER INTESTINAL ISCHEMIA/REPERFUSION

Yusuke Takizawa, Aiko Iida, Mayuko Nagira, Mikio Tomita, Masahiro Haya ...

Session ID: 01D11-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.259.1

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EFFECT OF ALTERATION OF CAR ON BILIRUBIN DETOXIFICATION IN MICE COLLAGEN-INDUCED ARTHRITIS

Atsushi Kawase, You Tsunokuni, Masahiro Iwaki

Session ID: 01D11-4
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_259_2

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DEVELOPMENT OF SIMULTANEOUS AND HIGHLY SELECTIVE AND SENSITIVE LC-MS/MS METHOD FOR THE DIRECT QUANTIFICATION OF MEMBRANE TRANSPORTER PROTEIN

Junichi Kamiie, Yuki Katsukura, Yumi Sekine, Kazunari Yanai, Satoshi U ...

Session ID: 01A13-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.260.1

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CHENODEOXYCHOLIC ACID-BINDING PROTEIN IN RAT HYPOPHYSIS

Kohei Abe, Koichi Sato, Takaaki Goto, Nariyasu Mano, Junichi Goto

Session ID: 01A13-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_260_2

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MESSENGER RNA EXPRESSION OF HUMAN CYTOCHROME P450S AND TRANSCRIPTION FACTORS IN FLC4-BIOS-1 CELLS CULTURED ON CELL ARRAYS

Mai Hirano, Kaoru Kobayashi, Norihiko Iwazaki, Tomomi Furihata, Seiji ...

Session ID: 01A13-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.261.1

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MDR1 T-129C POLYMORPHISM CAN BE PREDICTIVE OF DIFFERENTIATION, AND THEREBY PROGNOSIS OF COLORECTAL ADENOCARCINOMA IN JAPANESE

Daisuke Yamasaki, Tatsuya Koyama, Tsutomu Nakamura, Mayuko Taniguchi, ...

Session ID: 01A14-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_261_2

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DRUG-INDUCED HEPATOTOXICITY ASSAY USING ADENOVIRUS VECTOR-MEDIATED KNOCKDOWN OF GAMMA-GLUTAMYLCYSTEINE SYNTHETASE BY SHORT HAIRPIN RNA

Sho Akai, Hiroko Hosomi, Keiichi Minami, Miki Katoh, Miki Nakajima, Ts ...

Session ID: 01A14-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.262.1

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ALLOSTERIC MODULATION OF UDP-GLUCURONOSYLTRANSFERASE BY ENDOGENOUS ADENINE NUCLEOTIDES AND RELATED SUBSTANCES

Yoshio Nishimura, Shingo Maeda, Peter I. Mackenzie, Yuji Ishii, Hideyu ...

Session ID: 01B13-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.263.1

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EFFECT OF HYPOMAGNESEMIA ON THE EXPRESSION AND FUNCTION OF ORGANIC ANION TRANSPORTERS, rOAT1 AND rOAT3, IN CISPLATIN-TREATED RAT KIDNEY

Kanako Yoshitome, Takanobu Matsuzaki, Hiroshi Watanabe, Akinobu Hamada ...

Session ID: 01B13-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_263_2

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IS GLUCOSE TRANSPORTER ASSOCIATED WITH CIRCADIAN VARIATION IN HYPOGLYCEMIC EFFECT OF TOLBUTAMIDE?

Makoto Miyazaki, Nobuhiro Takeda, Toshiki Fujii, Kazunori Iwanaga, Mas ...

Session ID: 01B13-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.264.1

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A SKIN CHOLESTEROL SULFOTRANSFERASE, St2b2, IS A TRIGGER OF CELL DIFFERENTIATION

Miki Shimada, Toshihiro Matsuda, Akira Sato, Takanori Akase, Kiyoshi N ...

Session ID: 01B14-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_264_2

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INTERINDIVIDUAL VARIABILITY OF ORGANIC ANION TRANSPORTER POLYPEPTIDE 1B1 MESSENGER RNA EXPRESSION IN HUMAN LIVER

Tomomi Satoh, Tomomi Furihata, Naoko Yamamoto, Kaoru Kobayashi, Kan Ch ...

Session ID: 01B14-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.265.1

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INVOLVEMENT OF CARRIER-MEDIATED TRANSPORT IN CLONIDINE UPTAKE BY EVERTED SACS OF THE RAT SMALL INTESTINE

Naoya Sano, Katsuhisa Inoue, Yayoi Hayashi, Hiroaki Yuasa

Session ID: 01C13-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.266.1

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Investigation of the transporters responsible for the hepatobiliary transport of a novel angiotensin II receptor antagonist, telmisartan acylglucuronide

Naoki Ishiguro, Kazuya Maeda, Asami Saito, Ebner Thomas, Willy Roth, T ...

Session ID: 01C13-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_266_2

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Cooperation of concentrative nucleoside transporter (CNT) and equilibrative nucleoside transporter (ENT) in the uptake of ribavirin.

Takashi Yamamoto, Yoh Takekuma, Takeshi Hirano, Ken Iseki, Seiji Miyau ...

Session ID: 01C13-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.267.1

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EVALUATION OF FOLIC ACID TRANSPORT IN HUMAN PLACENTAL TROPHOBLASTS

Satoko Hasui, Satoru Yasuda, Masaki Kobayashi, Shirou Itagaki, Takeshi ...

Session ID: 01C14-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_267_2

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AMRUBICIN AND ITS ACTIVE METABOLITE AMRUBICINOL ARE SUBSTRATES OF P-GLYCOPROTEIN

Asumi Hira, Hiroshi Watanabe, Yusuke Matsunaga, Yukiko Maeda, Akinobu ...

Session ID: 01C14-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.268.1

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Poster Presentations

MODIFIED CACO-2 PERMEABILITY ASSAY USING 96-WELL PLATE FOR 4 DAYS

Masashi Uchida, Tominaga Fukazawa, Yuri Yamazaki, Hisashi Hashimoto, Y ...

Session ID: 29PE-01
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.270.1

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PHARMACOKINETICS AND HEPATIC EXTRACTION OF METOPROLOL IN RATS WITH GLYCEROL-INDUCED ACUTE RENAL FAILURE

Hiroko Tanabe, Shigehiro Taira, Masato Taguchi, Yukiya Hashimoto

Session ID: 29PE-02
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_270_2

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MECHANISM OF LIMITED ORAL ABSORPTION OF CYCLOSPORIN A: ROLES OF P-GLYCOPROTEIN AND CYTOCHROME P450 3A

Mingji Jin, Koichi Yokogawa, Ken-ichi Miyamoto

Session ID: 29PE-03
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.271.1

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CIRCADIAN RHYTHM OF MIDAZOLAM CLEARANCE IN CRITICALLY ILL JAPANESE PATIENTS: POPULATION PHARMACOKINETIC ANALYSIS

Takahiko Aoyama, Kiyotaka Hirata, Arimichi Kikuchi, Yasuhiro Yamamoto, ...

Session ID: 29PE-04
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_271_2

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PHARMACOKINETICS OF HIV PROTEASE INHIBITORS, ATAZANAVIR AND NELFINAVIR IN DIABETES AND HYPERLIPIDEMIA MODEL RATS

Kenji Sato, Kenji Ota, Kazuyo Kitamura, Yuta Maeda, Ikuhiro Shimo, Kei ...

Session ID: 29PE-05
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.272.1

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TRANSPORT CHARACTERISTICS OF ISOTAXE L, A NOVEL WATER-SOLUBLE PACLITAXEL PRODRUG, ACROSS CACO-2 MONOLAYERS

Yuka Suehisa, Yoshio Hayashi, Mariusz Skwarczynski, Akira Yamamoto, Yo ...

Session ID: 29PE-06
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_272_2

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EFFECT OF UV-IRRADIATION ON DERMAL PHARMACOKINETICS OF KETOPROFEN AND ITS PHOTOPRODUCTS IN GUINEA PIGS

Kaori Adachi, Yoshitaka Matsuzaki, Yukiko Komori, Tomoyuki Furubayashi ...

Session ID: 29PE-07
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.273.1

CONFERENCE PROCEEDINGS FREE ACCESS

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