Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics

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21st JSSX Annual Meeting

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Poster Presentations

A NOVEL FEATURE OF ANDROGRAPHOLIDE AS A MULTI-POTENTIAL INDUCER OF CYTOCHROME P450 ENZYMES

Atika Jaruchotikamol, Kanokwan Jarukamjorn, Sumiyo Itoh, Tsutomu Sakum ...

Session ID: 29PE-58
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_298_2

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IN VITRO INDUCTION ASSAY OF CYTOCHROME P450 USING IMMORTALIZED HUMAN HEPATOCYTES

Junko Yamamoto, Naoko Furukawa, Shirou Kirita, Yoshimasa Kyokawa, Nobu ...

Session ID: 29PE-59
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.299.1

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FEASIBILITY AND VALIDATION OF CYP1A AND CYP3A INDUCTION IN HepaRG, A NOVEL HUMAN CELL LINE OBTAINED FROM A DIFFERENTIATED HEPATOMA

Nobuyuki Murayama, Osamu Okazaki, Kaoru Shimada, Kunihiko Mizuno, Momo ...

Session ID: 29PE-60
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_299_2

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Developmental Changes of Cytochrome P450 and Induction by Xenobiotics in Rat Fetal and Neonatal Liver

Miyuki Arai, Yuta Fujieda, Kazumi Sugihara, Shigeyuki Kitamura, Shiger ...

Session ID: 29PE-61
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.300.1

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EFFECTS OF INTESTINAL MICROFLORA ON THE EXPRESSION OF HEPATIC AND INTESTINAL CYP3A

Naoko Saito, Takahiro Toda, Ayaka Maniwa, Masataka Tajima, Toshiyuki K ...

Session ID: 29PE-62
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_300_2

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EFFCTS OF FLUORINE-SUBSTITUTION ON THE CYP2C9-INHIBITING ACTIVITY OF BENZO[H]QUINOLINE

Noriko Matsuyama, Takaharu Mizutani, Ken-ichi Saeki

Session ID: 29PE-63
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.301.1

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Inhibitory effect of phthalate diesters and parabens on the cytochrome P450 system

Hitomi Ozaki, Shigeyuki Kitamura, Kazumi Sugihara, Shigeru Ohta

Session ID: 29PE-64
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_301_2

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THE INHIBITORY EFFECT OF POLYUNSATURATED FATTY ACIDS ON HUMAN CYP ENZYMES

Hsien-Tsung Yao, Yi-Wei Chang, Shih-Jung Lan, Chiung-Tong Chen, John T ...

Session ID: 29PE-65
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.302.1

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ROLE OF INFLAMMATORY MEDIATORS IN DOWN-REGULATION OF HEPATIC CYTOCHROME P450 IN THE RAT WITH TNBS-COLITIS

Yasuhiro Masubuchi, Kanako Enoki, Toshiharu Horie

Session ID: 29PE-66
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_302_2

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DRUG METABOLISM RELATED GENE EXPRESSION PROFILES IN PHENOBARBITAL OR β-NAPHTHOFLAVONE ADMINISTERED RAT LIVER, KIDNEY AND SMALL INTESTINE USING 24 SAMPLES ANALYZABLE DNA MICROARRAY

Isao Miyagawa, Atsushi Morishita, Kazuyuki Yanagibashi, Kazuhiko Kogoh

Session ID: 29PE-67
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.303.1

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REGULATION OF Cyp3a41 AND Cyp3a44 GENE EXPRESSION MEDIATED BY GLUCOCORTICOID RECEPTOR

Wattanaporn Bhadhprasit, Tsutomu Sakuma, Masahiro Fuwa, Shin-ichi Ueno ...

Session ID: 29PE-68
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_303_2

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A ROLE OF AMPK IN CYP2B INDUCTION in vivo

Sawako Shindo, Satoshi Numazawa, Takemi Yoshida

Session ID: 29PE-69
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.304.1

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Effects of flavonoids on AhR and HIF-1alpha systems

Tomoko Sawada, Susumu Imaoka

Session ID: 29PE-70
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_304_2

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RAPID GENOTYPING OF CYP2A6 ALLELES BY FLUORESCENCE RESONANCE ENERGY TRANSFER

Kazuma Kiyotani, Masaki Fujieda, Asami Muroi, Tetsuya Kamataki

Session ID: 29PE-71
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.305.1

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VISUALIZATION OF PATTERN OF CYP-METABOLISMS OF DRUGS USING A NOVEL HIERARCHICAL DATA VISUALIZATION TECHNIQUE

Hideto Hara, Fumiyoshi Yamashita, Takayuki Itoh, Mitsuru Hashida

Session ID: 29PE-72
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_305_2

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THE LONG-TERM MAINTENANCE OF METABOLIC ACTIVITIES IN 3-DIMENSIONAL CULTURE USING RAT HEPATOCYTES HOLLOW FIBERS

Kaori Murakoshi, Yasuhiro Yamada

Session ID: 29PE-73
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.306.1

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IDENTIFICATION OF HUMAN CYTOCHROME P450 ISOZYMES INVOLVED IN DIPHENHYDRAMINE N-DEMETHYLATION

Tomoko Akutsu, Kaoru Kobayashi, Koichi Sakurada, Hiroshi Ikegaya, Tomo ...

Session ID: 29PE-74
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_306_2

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CYP2C76-MEDIATED SPECIES DIFFERENCE IN DRUG METABOLISM: A COMPARISON OF PITAVASTATIN METABOLISM BETWEEN MONKEYS AND HUMANS

Hideki Fujino, Yasuhiro Uno, Takayuki Kumano, Go Kito, Ryoichi Nagata, ...

Session ID: 29PE-75
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.307.1

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INVESTIGATION OF DEBRISOQUINE HYDROXYLATION BY MARMOSET LIVER MICROSOMES

Brian R. Cooke, S. W. Annie Bligh, Costas Ioannides, G. Gordon Gibson, ...

Session ID: 29PE-76
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_307_2

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FUNCTIONAL CHARACTERIZATION OF TWO NOVEL CYP2C19 VARIANTS (CYP2C19^*18 AND CYP2C19^*19) FOUND IN A JAPANESE POPULATION

Yumi Tsuneto, Nobumitsu Hanioka, Yoshiro Saito, Tomoko Sumada, Keiko M ...

Session ID: 29PE-77
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.308.1

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STRAIN DIFFERENCE OF IN VIVO AND IN VITRO METABOLISM OF ZALEPLON IN RATS

Chiaki Tanoue, Manami Hirata, Kazumi Sugihara, Shigeyuki Kitamura, Shi ...

Session ID: 29PE-78
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_308_2

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PARTICIPATION OF CYP2C19, CYP3A4, AND CYP3A7 IN N-OXIDATED AND UNKONWN METABOLITES FORMATION FROM VORICONAZOLE BY HUMAN LIVER MICROSOMES

Naoko Imai, Norie Murayama, Makiko Shimizu, Hiroshi Yamazaki

Session ID: 29PE-79
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.309.1

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FUNCTIONAL CHARACTERIZATION OF SEVEN NOVEL ALLELES OF CYP2C9 FOUND IN JAPANESE

Keiko Maekawa, Hiromi Fukushima-Uesaka, Masahiro Tohkin, Ryuichi Haseg ...

Session ID: 29PE-80
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_309_2

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PRESENCE AND ROLE OF DRUG-METABOLIZING ENZYMES IN RAT BRAIN AND LUNG MICROVASCULAR ENDOTHELIAL CELLS. IDENTIFICATION OF CYP2C13

Akio Nomura, Eiichi Sakurai

Session ID: 29PE-81
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.310.1

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DETERMINATION OF REGULATORY REGION FOR TRANSCRIPTION OF MOUSE Cyp2b9 GENE

Tadahiro Hashita, Asuka Nakajima, Mami Akada, Tsutomu Sakuma, Nobuo Ne ...

Session ID: 29PE-82
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_310_2

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CHARACTERIZATION OF NINE CYTOCHROME P450 CDNAS IN CYNOMOLGUS MONKEY

Yasuhiro Uno, Shinya Hosaka, Kiyomi Matsuno, Chika Nakamura, Go Kito, ...

Session ID: 29PE-83
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.311.1

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INVOLVEMENT OF TRANSPORT SYSTEM IN HEPATIC UPTAKE OF AN ACTIVE METABOLITE OF PRODRUG-TYPE NEW QUINOLONE ANTIBIOTIC, PRULIFLOXACIN

Yukihiro Yagi, Makoto Aoki, Maki Iguchi, Shigeki Shibasaki, Toru Kuros ...

Session ID: 29PE-84
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_311_2

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HIGH-THROUGHPUT PLASMA PROTEIN BINDING ASSAY USING 96-WELL EQUILIBRIUM DIALYSIS APPARATUS

Tetsuya Tamura, Mayumi Mizutani

Session ID: 29PE-85
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.312.1

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The new acyl-CoA cholesterol acyltransferase inhibitor SMP-797 does not interact with statins via OATP1B1 in human cryopreserved hepatocytes and oocytes expressing systems.

Atsushi Kitamura, Satoki Imai, Masashi Yabuki, Setsuko Komuro, Yoshiak ...

Session ID: 29PE-86
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_312_2

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CHARACTERISTICS OF SUBSTRATES UPTAKE INTO TRANSPORTER EXPRESSING OOCYTES

Yasuhisa Adachi, Kyoko Hirano, Shin-ichiro Nagatsuka, Shin-ichi Ninomi ...

Session ID: 30PE-01
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.314.1

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IMMUNOHISTOCHEMICAL LOCALIZATION OF AN ALDO-KETO REDUCTASE IN RAT TISSUES

Satoshi Endo, Kenji Horie, Toshiyuki Matsunaga, Isao Nakamura, Yasuo B ...

Session ID: 30PE-02
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_314_2

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TRANSPORT MECHANISM OF ORGANIC CATIONS IN HUMAN ALVEOLAR EPITHELIAL CELL LINE A549

Toshihiro Sato, Naoki Ishiguro, Masanobu Oyabu, Tomoji Maeda, Ikumi Ta ...

Session ID: 30PE-03
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.315.1

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ESTIMATION OF THE ELIMINATION PATHWAY OF OTERACIL POTASSIUM IN HUMAN

Ikuo Yamamiya, Kunihiro Yoshisue, Masahito Komuro, Sekio Nagayama

Session ID: 30PE-04
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_315_2

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DECREASED DISTRIBUTION OF AN ORGANIC CATION, TRIETHYLMETHYLAMMONIUM TO THE KIDNEY IN RATS WITH URANYL NITRATE-INDUCED ACUTE RENAL FAILUAR IN ASSOCIATION WITH rOCT2-SPECIFIC IMPAIRMETN

Joo-Hyun Park, Hong Li, Dae-Duk Kim, Suk-Jae Chung, Chang-Koo Shim

Session ID: 30PE-05
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.316.1

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THE ESTABLISHMENT OF IN VITRO AIRWAY DRUG DELIVERY MODEL USING AIR-LIQUID INTERFACE (ALI) STATE OF HUMAN BRONCHIAL EPITHELIAL CELL MONOLAYERS

Ji-Woong Cheon, Hongxia Lin, Hong Li, Suk-Jae Chung, Chang-Koo Shim, D ...

Session ID: 30PE-06
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_316_2

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DEVELOPMENT OF NOVEL DRUG DELIVERY SYSTEM BASED ON ORGAN-SELECTIVE INHIBITION OF DRUG ELIMINATION BY ORGAN SURFACE APPLICATION OF PROBENECID AS A MODEL

Koyo Nishida, Junya Nishi, Shintaro Fumoto, Mikiro Nakashima, Hitoshi ...

Session ID: 30PE-07
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.317.1

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IN VIVO EVALUATION OF NUCLEAR FACTOR KAPPA B OF VARIOUS ORGANS IN RAT CARDIAC ALLOGRAFT REJECTION

Mieko Iwai, Yuriko Higuchi, Shigeru Kawakami, Kiyoshi Mihara, Yusuke T ...

Session ID: 30PE-08
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_317_2

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LIVER LOBE-SPECIFIC GENE TRANSFER FOLLOWING THE CONTINUOUS MICROINSTILLATION OF PLASMID DNA ONTO THE LIVER SURFACE IN MICE

Junzo Nakamura, Shintaro Fumoto, Mayumi Tsuchimochi, Yukinobu Kodama, ...

Session ID: 30PE-09
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.318.1

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The identification of P-gp expression in Air-Liquid Interface(ALI) culture of human nasal epithelial cell monolayers

Hyun-Jong Cho, Eun-A Lee, Hongxia Lin, Suk-Jae Chung, Chang-Koo Shim, ...

Session ID: 30PE-10
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_318_2

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NONLINEAR KINETICS OF TACRINE DISTRIBUTION TO THE BRAIN IN RATS: EVIDENCE OF ROCT2 IN THE TRANSPORT

Kyung-Ha Yu, Dae-Duk Kim, Chang-Koo Shim, Suk-Jae Chung

Session ID: 30PE-11
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.319.1

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EFFECT OF MANNOSE DENSITY ON MANNOSE RECEPTOR-MEDIATED CELLULAR UPTAKE OF MANNOSYLATED LIPOSOMES BY PRIMARY CULTURED ALVEOLAR MACROPHAGES

Wassana Yeeprae, Shigeru Kawakami, Mitsuko Takenaga, Rie Igarashi, Fum ...

Session ID: 30PE-12
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_319_2

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ASSESSMENT OF GENE EXPRESSION IN DRUG METABOLIZING ENZYMES USING A 24-SAMPLE DNA MICROARRAY

Michiko Sugawara, Kenji Matsui, Kazutomi Kusano, Tsutomu Yoshimura

Session ID: 30PE-13
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.320.1

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DEVELOPMENT OF IN VITRO HIGH THROUGHPUT METABOLIC STABILITY ASSAY IN THE EARLY DRUG DISCOVERY STAGE

Chie Emoto, Shigeo Murase, Akifumi Tanaka, Misaki Kuroda, Emi Yamada, ...

Session ID: 30PE-14
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_320_2

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REAL-TIME MONITORING OF CELL GROWTH RATE BY MEANS OF ELECTROCHEMICAL IMPEDANCE MEASUREMENT

Masaaki Kobayashi, Nobuhiro Sugihara, Takeshi Omasa, Tamihide Matsunag ...

Session ID: 30PE-15
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.321.1

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APPLICATION OF A SAMPLE POOLING METHOD FOR THE ACCELERATED ASSESSMENT OF THE RATE OF UPTAKE OF DRUGS BY THE BRAIN IN RATS

Han-Joo Maeng, Dae-Duk Kim, Chang-Koo Shim, Suk-Jae Chung

Session ID: 30PE-16
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_321_2

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RAPID SCREENING OF THE ANTINEOPLASTIC CANDIDATES FOR OATP1B3 SUBSTRATES USING FLUORESCENT PROBES

Minako Kobayashi, Hiroaki Yamaguchi, Masahiro Okada, Takaaki Abe, Mich ...

Session ID: 30PE-17
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.322.1

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THE DEVEROPMENT OF ANTIPYRETIC ANALGESICS WHICH DO NOT PRODUCE ALLERGIC REACTIONS

Naoto Uramaru, Hiroshi Saito, Tadashi Watabe, Akihisa Toda, Reiko Eyan ...

Session ID: 30PE-18
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_322_2

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A CHARACTERIZATION OF N-GLUCURONIDATION OF FYX-051, A NEW XANTHINE OXIDOREDUCTASE INHIBITOR

Koichi Omura, Takashi Nakazawa, Osamu Nagata

Session ID: 30PE-19
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.323.1

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CURRENT FDA'S DRAFT DRUG-DIAGNOSTIC CO-DEVELOPMENT CONCEPT PAPER: KEY ISSUES FROM INDUSTRY PERSPECTIVE

Takashi Horikawa, Sohei Tanabe, Yoshihide Goto, Akio Ohtani, Shinsaku ...

Session ID: 30PE-20
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_323_2

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CHARACTERIZATIONS ON GINSENOSIDE RG₃-MEDIATED 5-HT₃A RECEPTOR REGULATIONS

Byung-Hwan Lee, Sang Min Jeong, Jong-Hoon Kim, Jun-Ho Lee, In-Soo Yoon ...

Session ID: 30PE-21
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.324.1

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