Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics

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21st JSSX Annual Meeting

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Poster Presentations

Improvement of Intestinal Absorption by Peptide-Derivation of Nonabsorbable Drug via Peptide Transporter PEPT1

Akihiro Kikuchi, Michinori Tanaka, Takahiro Tomoyasu, Tomoji Maeda, Ik ...

Session ID: 29PE-08
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_273_2

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IMPROVED INTESTINAL MEMBRANE PERMEABILITY OF QUINOLINE-HEXOSE DERIVATIVES VIA HEXOSE TRANSPORTER SGLT1

Katsumasa Otake, Hiroshi Suzuki, Ryunosuke Higashi, Hikaru Yabuuchi, T ...

Session ID: 29PE-09
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.274.1

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SPERMINATED PULLULAN AS AN ABSORPTION ENHANCER FOR PULMONARY-ADMINISTERED INSULIN

Kazuhiro Morimoto, Nanako Fukushi, Sumio Chono, Yasuhiko Tabata, Toshi ...

Session ID: 29PE-10
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_274_2

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EVALUATION OF SKIN PERMEATION OF NANOPARTICLES WITH 2-METHACRYLOYLOXYETHYL PHOSPHORYLCHOLINE (MPC) ACYLMETHACRYLATE COPOLYMER IN VITRO

Yuka Shimoyama, Nozomi Takeda, Kozue Fujii, Naoya Koizumi, Makiko Fuji ...

Session ID: 29PE-11
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.275.1

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OPTIMIZATION OF IN VITRO ADME EXPERIMENTAL METHODS FOR WATER-INSOLUBLE COMPOUNDS

Takahiro Sugimoto, Kazunori Iwanaga, Makoto Miyazaki, Masawo Kakemi

Session ID: 29PE-12
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_275_2

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THE IMPACT OF PHYSICOCHEMICAL PROPERTIES OF COMPOUNDS ON THEIR ABSORPTION PROFILES IN VIVO

Yusuke Fujieda, Satomi Kanki, Toshiki Tabata, Kayoko Ike, Atsuto Ogata

Session ID: 29PE-13
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.276.1

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EFFECTS OF ACANTHOPANAX SENTICOSUS ON THE INTESTINAL DRUG TRANSPORTERS IN CACO-2 CELLS

Tomomi Kaku, Tsunehisa Takahashi, Takashi Sato, Hiroshi Yamashita, Kaz ...

Session ID: 29PE-14
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_276_2

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ESSENTIAL MOLECULAR FEATURES OF SUBSTRATES VIA HUMAN SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER (hSMCT)

Seiji Miyauchi, Rui Sakaki, Shiro Itagaki, Ken Iseki, Mitsuru Sugawara ...

Session ID: 29PE-15
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.277.1

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MOLECULAR IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF A pH-SENSITIVE FOLATE TRANSPORTER IN HUMAN INTESTINE

Yasuhiro Nakai, Katsuhisa Inoue, Mai Hatakeyama, Yayoi Hayashi, Hiroak ...

Session ID: 29PE-16
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_277_2

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QUANTITATIVE STRUCTURE-PERMEABILITY RELATIONSHIP OF HYDROPHOBIC COMPOUNDS WITH ARTIFICIAL MEMBRANES

Masaaki Fujikawa, Kazuya Nakao, Ryo Shimizu, Miki Akamatsu

Session ID: 29PE-17
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.278.1

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VARIATION OF FUNCTION AND EXPRESSION OF VARIOUS TRANSPORTERS IN CACO-2 CELLS DURING CULTURE DAYS

Emi Kamiyama, Eiji Shigehara, Daisuke Sugiyama, Shin-ichi Miura, Toshi ...

Session ID: 29PE-18
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_278_2

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In vitro permeation of several drugs into skins from humans, pigs, dogs, rats, and hairless mice, and into the human nail plate

Hiroo Moriyama, Kenji Tasaki, Tomoya Ueda, Kaori Kawakami, Chiemi Irit ...

Session ID: 29PE-19
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.279.1

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EFFECT OF WATER SOLUBILIZATION OF α-TOCOPHEROL ON THE PHARMACOKINETICS AFTER ORAL ADMINISTRATION IN RATS

Keita Hirai, Shinya Uchida, Hina Chikamori, Junya Hatanaka, Shizuo Yam ...

Session ID: 29PE-20
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_279_2

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UPTAKE OF MCPA (4-CHLORO-2-METHYLPHENOXYACETIC ACID) FROM THE APICAL MEMBRANE OF CACO-2 CELLS BY THE MONOCARBOXYLIC ACID TRANSPORTERS

Osamu Kimura, Kensuke Tsukagoshi, Tetsuya Endo

Session ID: 29PE-21
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.280.1

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PREDICTION OF IN VIVO POTENTIAL FOR METABOLIC ACTIVATION OF DRUGS: CORRELATION OF IN VITRO AND IN VIVO GENERATION OF REACTIVE INTERMEDIATES AND IN VITRO GLUTATHIONE CONJUGATE FORMATION

Noriko Masubuchi, Chie Makino, Nobuyuki Murayama, Hiroshi Kikuchi, Ken ...

Session ID: 29PE-22
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_280_2

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A novel method for evaluating the potential of reactive intermediates formation by using [³⁵S]cysteine and [¹⁴C]cyanide as nucleophilic trapping reagents

Kazuko Inoue, Yoshihiro Shibata, Hiroyuki Takahashi, Masato Chiba, Yas ...

Session ID: 29PE-23
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.281.1

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DETERMINATION OF REACTIVE METABOLITES IN VITRO USING GLUTATHIONE TRAP METHOD

Chiharu Yamada, Yasuhisa Adachi, Shin-ichiro Nagatsuka, Shin-ichi Nino ...

Session ID: 29PE-24
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_281_2

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PHARMACOKINETICS OF ANTI-SARS-COV AGENT NICLOSAMIDE AND ITS ANALOGS IN RATS

Yi-Wei Chang, Teng-Kuang Yeh, Ke-Ta Lin, Wei-Cheng Chen, Hsien-Tsung Y ...

Session ID: 29PE-25
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.282.1

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CAPILLARY ELECTROPHORESIS WITH LASER-INDUCED FLUORESCENCE DETECTION FOR THE DETERMINATION OF CAFFEIC ACID IN SMALL VOLUMES OF RAT PLASMA

Chen-Hsi Chou, Ying Zao, Ching-Ling Cheng

Session ID: 29PE-26
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_282_2

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DETERMINATION OF ZONISAMIDE AND ITS METABOLITE, 2-SULPHAMOYLACETYLPHENOL, IN HUMAN LIVER CYTOSOL AND MICROSOMES USING LC-MS/MS

Mitsuhiro Nakamura, Masafumi Kubota, Eiji Takashima, Tadashi Sugiyama, ...

Session ID: 29PE-27
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.283.1

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DETERMINATION OF VARDENAFIL IN SMALL VOLUMES OF RAT PLASMA AND BILE USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY WITH FLUORESCENCE DETECTION

Ching-Ling Cheng, Guei-Jen Kang, Chen-Hsi Chou

Session ID: 29PE-28
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_283_2

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LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY (LC-MS/MS) FOR DETERMINATION OF BENZODIAZEPINES IN HUMAN PLASMA USING AN ODS COLUMN COMPATIBLE FOR HYDROPHILIC COMPOUNDS

Tomofumi Ohmori, Mitsuhiro Nakamura, Tadashi Sugiyama, Kazuyuki Hirano

Session ID: 29PE-29
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.284.1

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C-Glucuronidation of phenylbutazone by human UDP-glucuronosyltransferase 1A9

Takahito Nishiyama, Tomihiro Kobori, Kouji Arai, Kenichiro Ogura, Tomo ...

Session ID: 29PE-30
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_284_2

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SULFATION OF CHENODEOXYCHOLIC ACID BY RAT BRAIN CYTOPLASMIC FRACTION

Nariyasu Mano, Shin-ichiro Abe, Masamitsu Maekawa, Khin Than Myint, Ta ...

Session ID: 29PE-31
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.285.1

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SPECIFIC ANALYSIS OF SMALL MOLECULE-BINDING PROTEINS

Koichi Sato, Nariyasu Mano, Junichi Goto

Session ID: 29PE-32
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_285_2

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ELUCIDATION ON UNIQUE PHARMACOKINETIC PROFILE OF FINASTERIDE BY A MODEL ANALYSIS INCLUDING ITS BINDING TO TESTOSTERONE 5-ALPHA-REDUCTASE

Takatoshi Takubo, Hisao Ochiai, Ikuo Aoki, Akiko Kano, Takuma Matsuda, ...

Session ID: 29PE-33
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.286.1

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QUANTITATIVE PREDICTION OF HUMAN INTESTINAL AVAILABILITY OF CYP3A4 SUBSTRATES BASED ON UNBOUND CONCENTRATION

Yumiko Iwase, Masataka Ishiji, Tomoya Narawa, Yasuyuki Tsuda, Tomoo It ...

Session ID: 29PE-34
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_286_2

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NONLINEAR FIRST PASS METABOLISM OF MIDAZOLAM IN RAT

Yoshiaki Negi, Kazuho Okudaira, Ryuichiro Nishigaki

Session ID: 29PE-35
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.287.1

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PHARMACOKINETICS AND METABOLITE PROFILES OF ¹⁴C-DIAZEPAM IN HUMAN PLASMA ANALYZED BY AMS AND LC/MS/MS IN A MICRODOSING STUDY

Yoshimi Hamabe, Emiko Hashimoto, Satomi Maruyama, Marika Shimoda, Mits ...

Session ID: 29PE-36
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_287_2

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ANALYSIS OF FACTORS AFFECTING PROPRANOLOL PHARMACOKINETICS IN RAT AND HUMAN USING A PHYSIOLOGICALL-BASED PHARMACOKINETIC MODEL

Akiko Kiriyama, Akino Honbo, Katsumi Iga

Session ID: 29PE-37
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.288.1

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COMPARISON OF IN-VITRO DISSOLUTION PROFILES OF GENERIC DILTIAZEM FORMULATIONS WITH INNOVATOR ONES AIMED TO DEVELOP AN IN-VITRO IN-VIVO CORRELATION (IVIVC)

Chiaki Hayashi, Sachie Nakayama, Hidekatsu Nishimura, Yukiko Komori, T ...

Session ID: 29PE-38
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_288_2

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PHARMACOKINETICS OF CYCLOSPORINE A IN RENAL ISCHEMIA-REPERFUSION INJURY MODEL RATS

Katsukuni Fujimoto, Mari Takai, Kosuke Yoshida, Saori Nakano, Yuka Tan ...

Session ID: 29PE-39
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.289.1

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EPIGENETIC REGULATION OF CYP1A2 IN MOUSE LIVER

Jin B, Yun P, Chang SI, Park CB, Dong-Young Ryu

Session ID: 29PE-40
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_289_2

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QUANTITATIVE DETECTION OF REACTIVE METABORITES USING FLUORESCENCE-TAGGED GLUTATHIONE

Chie Makino, Wataru Suzuki, Hideo Takakusa, Hiroshi Masumoto, Osamu Ok ...

Session ID: 29PE-41
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.290.1

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POPULATION PHARMACOKINETIC/PHARMACODYNAMIC ANALYSIS OF A GROWTH HORMONE RECEPTOR ANTAGONIST, PEGVISOMANT, IN JAPANESE AND WESTERN ACROMEGALY PATIENTS

Chieko Muto, Koji Chiba, Akiyuki Suzuki, Yoshiro Tomono, Eric Didier, ...

Session ID: 29PE-42
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_290_2

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APPROACH TO PREDICT THE CONTRIBUTION OF MAJOR CYTOCHROME ENZYMES TO DRUG METABOLISM IN THE EARLY DRUG DISCOVERY STAGE

Chie Emoto, Shigeo Murase, Kazuhide Iwasaki

Session ID: 29PE-43
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.291.1

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In Vivo Metabolism of S-Warfarin in Chimeric Mice with Humanized Liver

Tae Inoue, Kayoko Nitta, Shigeyuki Kitamura, Kazumi Sugihara, Toru Hor ...

Session ID: 29PE-44
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_291_2

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DIFFERENTIATION OF MONKEY EMBRYONIC STEM CELLS TO HEPATOCYTE AND EXPRESSION OF CYTOCHROME P450

Yasuyuki Momose, Tamihide Matsunaga, Kentaro Murai, Sayaka Mizukami, T ...

Session ID: 29PE-45
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.292.1

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UTILITY OF IMMORTALIZED HUMAN HEPATOCYTES IN INDUCTION STUDIES ON CYTOCHROME P450 AT THE DRUG DISCOVERY STAGE

Kazumi Ikeda, Yuko Ogasawara, Yasuhiro Yamada

Session ID: 29PE-46
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_292_2

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MECHANISM-BASED INHIBITION OF CYP3A4 BY TAO AND MIFEPRISTONE, AND CYP2D6 BY PAROXETINE, IN HUMAN LIVER MICROSOMES

Kiyomi Matsuno, Chika Nakamura, Kanako Yajima, Yasuharu Nakanishi, Hir ...

Session ID: 29PE-47
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.293.1

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DANAZOL AND ITS METABOLITES ACT AS MECHANISM-BASED INACTIVATORS IN MICE

Shiori Kuwana, Kazuho Okudaira, Keisuke Kato, Hiroyuki Akita, Ryuichir ...

Session ID: 29PE-48
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_293_2

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OPTIMIZATION OF CYTOCHROME P450 INHIBITORS FOR CYP IDENTIFICATION: INVESTIGATION OF SERECTIVITY FOR PROBE SUBSTRATE REACTIONS IN HUMAN LIVER MICROSOMES

Tomoko Inoue, Mizuki Horiuchi, Masashi Yabuki, Setsuko Komuro, Yoshiak ...

Session ID: 29PE-49
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.294.1

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THE USE OF HIGH-TEMPERATURE TREATMENT TO ELIMINATE DRUG INTERACTIONS DUE TO GRAPEFRUIT JUICE

Yoshihiro Uesawa, Kiminori Mohri

Session ID: 29PE-50
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_294_2

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EFFECT OF PSYCHOTROPIC DRUGS ON THE21-HYDROXYLATIUON OF NEUROSTEROIDS, PROGESTERONE AND ALLOPREGNANOLONE, CATALYZED BY RAT CYP2 D4 AND HUMAN CYP2D6 IN THE BRAIN

Toshiro Niwa, Kazushi Okada, Wataru Kishimoto, Susumu Imaoka, Shizuo N ...

Session ID: 29PE-51
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.295.1

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DO DATA FROM MINIPIGS HELP PREDICT IN VIVO DDI IN HUMANS?

Koichi Nakamura, Akiko Watanabe, Yoshimine Fujii, Masaru Iwasaki, Tsun ...

Session ID: 29PE-52
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_295_2

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INHIBITORY EFFECT OF THE FIRST GENERATION H1 RECEPTOR ANTAGONISTS ON CYTOCHROME P450 IN HUMAN LIVER MICROSOME

Mariko Iwase, Norimitsu Kurata, Yuki Nishimura, Hajime Yasuhar

Session ID: 29PE-53
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.296.1

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INTESTINAL DRUG-DRUG INTERACTIONS OF ORALLY ADMINISTERED DRUGS IN CYNOMOLGUS MONKEYS

Akihito Ogasawara, Isao Negishi, Emiko Kazama, Toshiyuki Kume

Session ID: 29PE-54
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_296_2

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DRUG-DRUG INTERACTION STUDIES OF SIMVASTATIN AS A CYP 3A PROBE IN CYNOMOLGUS MONKEYS

Masahiro Utoh, Akihito Ogasawara, Kazuo Nii, Ayumi Ueda, Takahiro Yosh ...

Session ID: 29PE-55
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.297.1

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MODULATION OF INTESTINAL EFFLUX TRANSPORTERS BY HERBAL MEDICINES

Tomoharu Yokooji, Nobuhiro Mori, Shin'ichi Yoshihara, Teruo Murakami

Session ID: 29PE-56
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_297_2

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Metabolism of Benzophenone-3, a Sunscreen Component, in Rats, and Activation of Estrogenic Activity

Shigeyuki Kitamura, Nagisa Kamikyoden, Kazumi Sugihara, Tsuyoshi Murah ...

Session ID: 29PE-57
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.298.1

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