In Japan, there are 24 indications for simple plasma exchange (PE); however, this number is lower than that in other countries. In addition, there have been few published studies dedicated to indications for simple PE in Japan.
This study aimed to elucidate the clinical background of patients who underwent PE at our hospital and examine its treatment course.
The study included patients who underwent PE in our department from January to December 2017. We retrospectively examined the data stored in the dialysis management system.
During the observational period, 42 patients [mean age, 49±18 years (mean±standard deviation); women, 52.4%] with 12 diseases underwent PE. Allogeneic kidney transplantation, which was the most common indication, was present in 17 (40.5%) patients. There were seven (16.6%) patients with focal glomerulosclerosis, seven (16.6%) patients with liver disease, and three (7.1%) patients with thrombotic microangiopathy. All the patients who underwent kidney transplantation, the renal function was maintained after kidney transplantation. In all patients with microangiopathy, the platelets increased and lactate dehydrogenase levels decreased. With respect to the adverse effects of the treatment, 19 (45.2%) patients experienced skin symptoms and two (4.8%) patients suffered from numbness.
We observed that PE performed at our hospital was effective for some of the indications. The outcome suggests that more studies reporting the indications for PE are required for expanding the number of indications for PE in Japan.
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