Non-selective intra-arterial (I-A) chemotherapy of paclitaxel plus platinum combination was performed in two dogs with cancers of the nasal cavity, including undifferentiated (Case 1) and transitional (Case 2) carcinomas. The drug dosages were reduced to 25% to 35.5% of the typical doses for systemic chemotherapy, and they were perfused via common carotid arteries. Case 1 had marked regression of the cancer but survived for only 53 days after the therapy. Case 2 had partial remission for approximately 3 months and survived for 126 days. Adverse events of the chemotherapies were not induced in Case 1, but mild adverse events were seen in Case 2. Non-selective I-A chemotherapy in this report required easy and simple procedures and could be safely performed via a reduction of the dosages of the drugs. Although future research will address issues concerning the intervals, frequencies, and drug dosages, the I-A chemotherapy was suggested as being able to contribute to palliative remission in canine intranasal cancers.
A 10-year-old castrated Miniature Dachshund with hypercalcemia showed normal serum levels of parathyroid hormone (PTH-intact) and parathyroid hormone-related protein (PTHrP). Computed tomography revealed no mass formations in the cervical area. However, serum concentration of 1α,25-dihydroxyvitamin D (1,25(OH)2D) was increased and a small nodule in the right thyroid gland was detected by using ultrasound. Therefore, the right total thyroidectomy was carried out. The resected mass was histopathologically diagnosed as a parathyroid adenoma. The patient showed no complications and clinical signs after surgery, and the serum calcium level decreased to the normal range. This case report suggests that the measurement of serum 1,25(OH)2D can be useful for finding out canine parathyroid adenoma patients with hypercalcemia, even when their serum PTH-intact and PTHrP levels are within the normal range.