Magnetic Resonance in Medical Sciences
Online ISSN : 1880-2206
Print ISSN : 1347-3182
ISSN-L : 1347-3182
Volume 19 , Issue 1
Showing 1-12 articles out of 12 articles from the selected issue
Brief Communication
Clinical Image
Major Papers
  • Barış Polat, Deniz Aydın, Ayşe Esin Polat, Tahsin Gürpınar, Ramadan Öz ...
    2020 Volume 19 Issue 1 Pages 7-13
    Published: 2020
    Released: February 10, 2020
    [Advance publication] Released: January 31, 2019

    Purpose: The aim of this study is to determine the prevalence of pathologic findings in asymptomatic knees of Kangoo Jumpers by using a 3T MRI and to compare them with age and sex-matched controls who do not regularly participate in any impact sports.

    Methods: Both knees of 18 Kangoo Jumpers were examined by 3T MRIs in a total of 36 MRI scans. The control group was comprised of 20 volunteers from the same age group and with similar weights who did not participate in any competitive sports, in a total of 40 MRI scans. Two orthopedists and one radiologist independently assessed all images for the presence or absence of any abnormalities.

    Results: In 32 (88.9%) of the 36 Kangoo Jumpers’ knees, one or more abnormalities were observed. The most prevalent abnormality was bone marrow edema, which was detected in 32 knees (88.9%). The other significant findings were quadriceps tendinopathy (80.6%), patellar tendinopathy (63.9%), gastrocnemius tendinopathy (63.9%), infrapatellar fat pad edema (75%), suprapatellar fat pad edema (63.9%), meniscal signal change (72.2%) and cartilage damage in the patellofemoral joint (72.2%). There were no statistically significant differences in terms of joint effusion (8.3%), ganglion cysts (8.3%) or tibiofemoral joint cartilage injury (0%).

    Conclusion: This study reveals many types of knee MRI findings of asymptomatic Kangoo Jumpers compared to the control group. These MRI findings may be associated with acute knee injuries or chronic joint problems such as osteoarthritis, which may develop in long-term follow-up studies.

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  • Yang Qing, Wang Xiong, Huang Da-xiang, Zhu Juan, Wang Fei, Yu Yong-qia ...
    2020 Volume 19 Issue 1 Pages 14-20
    Published: 2020
    Released: February 10, 2020
    [Advance publication] Released: April 05, 2019

    Purpose: To investigate whether the genu of the corpus callosum is involved in patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) type I.

    Methods: Twenty-three cases of clinically confirmed MERS I were analyzed retrospectively, and MRI features of the lesion were observed. The apparent diffusion coefficient (ADC) values of the same region of interests in lesions at the splenium and genu of the corpus callosum were measured before and after treatment (i.e., four groups), and the average ADC values were calculated. Paired t-tests were used to compare the ADC values of lesions in the splenium and genu before and after treatment. Independent sample t-tests were used to compare the values in the splenium and genu after treatment.

    Results: The mean ADC values of the splenium before and after treatment were 0.448 ± 0.124 and 0.790 ± 0.070 × 10−3 mm2/s, respectively, showing significant difference (P < 0.01). The mean ADC values in the genu before and after treatment were 0.783 ± 0.067 and 0.829 ± 0.070 × 10−3 mm2/s, respectively, also showing significant difference (P < 0.01). There was no significant difference in the ADC values between the splenium and genu after treatment (P > 0.05).

    Conclusion: The genu showed a slight restriction in diffusion in the acute stage of type I MERS. After treatment, this diffusion restriction diminished as it typically does in the splenium. Our results indicate that the pathology in MERS extends well beyond the visible lesions.

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  • Yuko Nakamura, Toru Higaki, Takashi Nishihara, Kuniaki Harada, Masahir ...
    2020 Volume 19 Issue 1 Pages 21-28
    Published: 2020
    Released: February 10, 2020
    [Advance publication] Released: March 18, 2019

    Purpose: Hepatobiliary-phase (HBP) MRI with gadoxetic acid facilitates the differentiation between lesions with and without functional hepatocytes. Thus, high-quality HBP images are required for the detection and evaluation of hepatic lesions. However, the long scan time may increase artifacts due to intestinal peristalsis, resulting in the loss of diagnostic information. Pseudo-random acquisition order disperses artifacts into the background. The aim of this study was to investigate the clinical applicability of pseudo-random trajectory scanning for the suppression of motion artifacts on T1-weighted images including HBP.

    Methods: Our investigation included computer simulation, phantom experiments, and a clinical study. For computer simulation and phantom experiments a region of interest (ROI) was placed on the area with motion artifact and the standard deviation inside the ROI was measured as image noise. For clinical study we subjected 62 patients to gadoxetic acid-enhanced hepatobiliary-phase imaging with a circular- and a pseudo-random trajectory (c-HBP and p-HBP); two radiologists graded the motion artifacts, sharpness of the liver edge, visibility of intrahepatic vessels, and overall image quality using a five-point scale where 1 = unacceptable and 5 = excellent. Differences in the qualitative scores were determined using the two-sided Wilcoxon signed-rank test.

    Results: The image noise was higher on the circular image compared with pseudo-random image (101.0 vs 60.9 on computer simulation image, 91.2 vs 67.7 on axial, 95.5 vs 86.9 on reformatted sagittal image for phantom experiments). For clinical study the score for motion artifacts was significantly higher with p-HBP than c-HBP imaging (left lobe: mean 3.4 vs 3.2, P < 0.01; right lobe: mean 3.6 vs 3.4, P < 0.01) as was the qualitative score for the overall image quality (mean 3.6 vs 3.3, P < 0.01).

    Conclusion: At gadoxetic acid-enhanced hepatobiliary-phase imaging, p-HBP scanning suppressed motion artifacts and yielded better image quality than c-HBP scanning.

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  • Shinichiro Seki, Yasuko Fujisawa, Masao Yui, Yuji Kishida, Hisanobu Ko ...
    2020 Volume 19 Issue 1 Pages 29-39
    Published: 2020
    Released: February 10, 2020
    [Advance publication] Released: March 18, 2019

    Purpose: To directly compare the utility for therapeutic outcome prediction of dynamic first-pass contrast-enhanced (CE)-perfusion area-detector computed tomography (ADCT), MR imaging assessed with the same mathematical method and 2-[fluorine-18]-fluoro-2-deoxy-d-glucose–positron emission tomography combined with CT (PET/CT) for non-small cell lung cancer (NSCLC) patients treated with chemoradiotherapy.

    Materials and Methods: Forty-three consecutive stage IIIB NSCLC patients, consisting of 25 males (mean age ± standard deviation: 66.6 ± 8.7 years) and 18 females (66.4 ± 8.2 years) underwent PET/CT, dynamic CE-perfusion ADCT and MR imaging, chemoradiotherapy, and follow-up examination. In each patient, total, pulmonary arterial, and systemic arterial perfusions were calculated from both perfusion data and SUVmax on PET/CT, assessed for each targeted lesion, and averaged to determine final values. Receiver operating characteristics analyses were performed to compare the utility for distinguishing responders from non-responders using Response Evaluation Criteria in Solid Tumor (RECIST) 1.1 criteria. Overall survival (OS) assessed with each index were compared between two groups by means of the Kaplan–Meier method followed by the log-rank test.

    Results: Area under the curve (Az) for total perfusion on ADCT was significantly larger than that of pulmonary arterial perfusion (P < 0.05). Az of total perfusion on MR imaging was significantly larger than that of pulmonary arterial perfusion (P < 0.05). Mean OS of responder and non-responder groups were significantly different for total and systemic arterial (P < 0.05) perfusion.

    Conclusion: Dynamic first-pass CE-perfusion ADCT and MR imaging as well as PET/CT are useful for early prediction of treatment response by NSCLC patients treated with chemoradiotherapy.

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  • Hiroko Tomita, Shigeyoshi Soga, Yohsuke Suyama, Keiichi Ito, Tomohiko ...
    2020 Volume 19 Issue 1 Pages 40-47
    Published: 2020
    Released: February 10, 2020
    [Advance publication] Released: March 26, 2019

    Purpose: Prostate cancer management includes identification of clinically significant cancers that may require curative treatment. Statistical models based on gamma distribution can describe diffusion signal decay curves of prostate cancer. The purpose of this study was to evaluate the ability of parameters obtained with the gamma model in differentiating prostate cancers with different Gleason score values.

    Methods: This study included 155 patients with prostate cancer who underwent multiparametric magnetic resonance imaging prior to prostate biopsy (127 patients) or radical prostatectomy (28 patients) between January 2015 and June 2017; 159 foci of prostate cancer were included in our study. We compared cases scored as Gleason score (GS) 3 + 3 and GS ≥ 3 + 4, and analyzed cases scored as GS ≤ 3+ 4 and GS ≥ 4 + 3 based on the gamma model (Frac < 1.0, Frac < 0.8, Frac < 0.5, Frac < 0.3, and Frac > 3.0), and apparent diffusion coefficient (ADC).

    Results: Among 159 cancerous lesions in 155 patients, 13 (8.2%) were GS 3 + 3 prostate cancers, 51 (32.0%) were GS 3 + 4 prostate cancers, 30 (18.2%) were GS 4 + 3 cancers, and 65 (40.9%) were GS ≥ 4 + 4 cancers. Frac < 0.3, Frac < 0.5, Frac < 0.8, and Frac < 1.0 were significantly higher and ADC values were significantly lower in GS ≥ 4 + 3 cancers than in GS ≤ 3 + 4 cancers (P < 0.01, P < 0.01, P < 0.01, P = 0.01, and P < 0.01, respectively). With receiver operating characteristic (ROC) analysis, Frac < 0.3 and Frac < 0.5 had significantly greater area under the ROC curve for discriminating GS ≥ 4 + 3 cancers from GS ≤ 3 + 4 cancers than ADC (P = 0.03, P < 0.01, respectively).

    Conclusion: Frac < 0.3 and Frac < 0.5 showed higher diagnostic performance than ADC for differentiating GS ≥ 4 + 3 from GS ≤ 3 + 4 cancers. The gamma model may add additional value in discrimination of tumor grades.

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  • Kosuke Morita, Takeshi Nakaura, Natsuki Maruyama, Yuji Iyama, Seitaro ...
    2020 Volume 19 Issue 1 Pages 48-55
    Published: 2020
    Released: February 10, 2020
    [Advance publication] Released: March 15, 2019

    Purpose: The hybrid compressed sensing (hybrid-CS) technique can shorten the acquisition time compared with the sensitivity encoding (SENSE) technique in lumbar MRI. To evaluate the feasibility of a hybrid-CS technique in comparison with 3D isotropic T2-weighted turbo spin-echo (3D volume isotropic turbo spin-echo acquisition [VISTA]) MRI of the lumbar spine.

    Materials and Methods: The Institutional Review Board approved this study and informed consent was obtained from participants prior to study entry. Sixteen healthy volunteers underwent lumbar spine 3D VISTA with conventional parallel imaging for SENSE and hybrid-CS at 3T. We recorded the image acquisition times of SENSE and hybrid-CS. We compared the signal-to-noise ratio (SNR) in spine, cerebrospinal fluid (CSF), lumbar disc, epidural fat, and erector spinae muscle, and the contrast of spine, CSF, and disc, and performed qualitative image analysis assessment, between the two image sequences.

    Results: The image acquisition time for hybrid-CS was 39.2% shorter than that of SENSE (218.4/358.8 s). The contrast of CSF and SNR of the spine was significantly higher with hybrid-CS than with SENSE (P < 0.05). The SNR of the disc and muscle was significantly higher with SENSE than with hybrid-CS (P < 0.05). There were no significant differences in the contrast of spine, disc, and fat, and SNR of CSF and fat between hybrid-CS and SENSE. There were no significant differences in the qualitative evaluation between hybrid-CS and SENSE.

    Conclusion: Compared with SENSE, hybrid-CS for 3D VISTA can shorten image acquisition time without sacrificing image quality.

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  • Lydia Chougar, Akifumi Hagiwara, Nao Takano, Christina Andica, Julien ...
    2020 Volume 19 Issue 1 Pages 56-63
    Published: 2020
    Released: February 10, 2020
    [Advance publication] Released: April 05, 2019

    Purpose: Flowing blood sometimes appears bright on synthetic T1-weighted images, which could be misdiagnosed as a thrombus. This study aimed to investigate the frequency of hyperintensity within cerebral venous sinuses on synthetic MR images and to evaluate the influence of increasing flow rates on signal intensity using a flow phantom.

    Materials and Methods: Imaging data, including synthetic and conventional MRI scans, from 22 patients were retrospectively analyzed. Signal intensities at eight locations of cerebral venous sinuses on synthetic images were graded using the following three-point scale: 0, “dark vessel”; 1, “hyperintensity within the walls”; and 2, “hyperintensity within the lumen.” A phantom with gadolinium solution inside a U-shaped tube was acquired without flow and then with increasing flow rates (60, 100, 200, 300, 400 ml/min).

    Results: Considering all sinus locations, the venous signal intensity on synthetic T1-weighted images was graded as 2 in 79.8% of the patients. On synthetic T2-weighted images, all sinuses were graded as 0. On fluid-attenuated inversion recovery (FLAIR) images, sinuses were almost always graded as 0 (99.4%). In the phantom study, the signal initially became brighter on synthetic T1-weighted images as the flow rate increased. Above a certain flow rate, the signal started to decrease.

    Conclusion: High signal intensity within the cerebral venous sinuses is a frequent finding on synthetic T1-weighted images. This corresponds to the hyperintensity noted at certain flow rates in the phantom experiment.

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  • Daiki Tamada, Marie-Luise Kromrey, Shintaro Ichikawa, Hiroshi Onishi, ...
    2020 Volume 19 Issue 1 Pages 64-76
    Published: 2020
    Released: February 10, 2020
    [Advance publication] Released: April 26, 2019

    Purpose: To improve the quality of images obtained via dynamic contrast enhanced MRI (DCE-MRI), which contain motion artifacts and blurring using a deep learning approach.

    Materials and Methods: A multi-channel convolutional neural network-based method is proposed for reducing the motion artifacts and blurring caused by respiratory motion in images obtained via DCE-MRI of the liver. The training datasets for the neural network included images with and without respiration-induced motion artifacts or blurring, and the distortions were generated by simulating the phase error in k-space. Patient studies were conducted using a multi-phase T1-weighted spoiled gradient echo sequence for the liver, which contained breath-hold failures occurring during data acquisition. The trained network was applied to the acquired images to analyze the filtering performance, and the intensities and contrast ratios before and after denoising were compared via Bland–Altman plots.

    Results: The proposed network was found to be significantly reducing the magnitude of the artifacts and blurring induced by respiratory motion, and the contrast ratios of the images after processing via the network were consistent with those of the unprocessed images.

    Conclusion: A deep learning-based method for removing motion artifacts in images obtained via DCE-MRI of the liver was demonstrated and validated.

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    Editor's Pick in August 2020

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  • Song Duan, Yurong Zhu, Feng Liu, Sherman Xuegang Xin
    2020 Volume 19 Issue 1 Pages 77-85
    Published: 2020
    Released: February 10, 2020
    [Advance publication] Released: April 24, 2019

    Purpose: Magnetic resonance electrical property tomography (MR EPT) is a technique for non-invasively obtaining the electric property (EP) distribution of biological tissues, with a promising potential for application in the early detection of tumors. However, the contrast capability (CC) of this technique has not been fully studied. This work aims to theoretically explore the CC for detecting the variation of EP values and the size of the imaging region.

    Methods: A simulation scheme was specifically designed to evaluate the CC of MR EPT. The simulation study has the advantage that the magnetic field can be accurately obtained. EP maps of the designed phantom embedded with target regions of designated various sizes and EPs were reconstructed using the homogeneous Helmholtz equation based on B1+ with different signal-to-noise ratios (SNRs). The CC was estimated by determining the smallest detectable EP contrast when the target region size was as large as the Laplacian kernel and the smallest detectable target region size when the EP contrast was the same as the difference between healthy and malignant tissues in the brain, based on the reconstructed EP maps.

    Results: Using noise free B1+, the smallest detectable contrastσ and contrastεr were 1% and 3%, respectively, and the smallest detectable target region size was 1 mesh unit (the base unit size used in the simulation) for conductivity and relative permittivity. The smallest detectable EP contrast and target region size were decreased as the B1+ SNR increased.

    Conclusion: The CC of MR EPT was related with the SNR of the magnetic field. A small EP contrast and size were necessary for detection at a high-SNR magnetic field. Obtaining a high-SNR magnetic field is important for improving the CC of MR EPT.

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