This review article outlines the challenges of current ex vivo lung perfusion (EVLP) methods and introduces a novel concept of organ preservation inspired by mammalian hibernation. Issues with conventional EVLP involve unsuitable perfusion fluids and problematic lung positioning. The new approach seeks to induce a low-metabolism state, similar to hibernation, in transplant organs, potentially enabling long-term preservation. This strategy, which aims to extend the perfusion time to 48 hours, could revolutionize organ transplantation, expanding the donor pool, and enhancing treatment possibilities such as stem cell therapy, gene therapy, and medical gas therapy.
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