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Volume 17 (2001)
- Issue 3 Pages 221-
- Issue 2 Pages 39-
- Issue 1 Pages 1-
Volume 17, Issue 2
Displaying 1-5 of 5 articles from this issue
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Eiko KATO2001 Volume 17 Issue 2 Pages 39-50
Published: 2001
Released on J-STAGE: September 07, 2009
JOURNAL FREE ACCESSThe observability of 68 males over three years of age in a free-ranging group of Japanese macaques (Macaca fuscata) at Katsuyama, Okayama Prefecture, was examined for five years (five birth and post-birth seasons and three mating and post-mating seasons). There were large individual differences in observability (percentage of days when the author observed the subject near the group at least once to the total observation days) among nine peripheral adult males, while six central males were constantly found near the group. Compared to peripheral adult males, the observability of younger males (three to seven years old at the start of the present study) gradually decreased with increasing age. On the other hand, the values for two sons and four grandsons of the α-female were much higher than those of other same-aged males, indicating that there was some delay in their leaving the natal group. The present results also suggest that observability during the six-month period that includes the mating season may be useful for assessing whether or not males will leave their natal group during the subsequent six-month period (birth season).View full abstractDownload PDF (2028K) -
Fusako MITSUNAGA, Shin NAKAMURA, Makoto HIRANO, Keiko SHIMIZU, Takahis ...2001 Volume 17 Issue 2 Pages 51-61
Published: 2001
Released on J-STAGE: September 07, 2009
JOURNAL FREE ACCESSGene therapy or DNA vaccination involves gene delivery systems and methods which influence on the efficacy and the risk of the gene transfer. Establishment of a monkey model to assess the efficiency and the safety of the materials is necessary, because monkeys have similar genomic nature, biomedical and immunological responses to those of humans.
Here we overview the structure of primate placenta, focusing on the maternofeto placental barrier to evaluate monkeys as an experimental model for gene transfer during pregnancy. Placentae of humans and monkeys are hemochorial type and have only one layer of trophoblast which contacts with maternal blood, while other conventional experimental animals (rats and mice) have two or three layers of the trophoblast. Thus, it is concluded that the monkey model is the most suitable to estimate the material transfer to fetuses through placenta.
We also showed gene transfer experiments on pregnant marmosets. In our study, GFP DNA/liposome vector was administered to marmosets at full term, and GFP DNA and GFP protein were both detected in fetal tissues. It indicates the necessity of careful administration of the liposome vectors during pregnancy and also suggests the feasibility of gene therapy and DNA vaccination to fetuses.View full abstractDownload PDF (2190K) -
Viktor REINHARDT, Annie REINHARDT, Katsura NAKAYAMA, Yoshikazu UENO, M ...2001 Volume 17 Issue 2 Pages 63-84
Published: 2001
Released on J-STAGE: September 07, 2009
JOURNAL FREE ACCESSDownload PDF (11265K) -
[in Japanese]2001 Volume 17 Issue 2 Pages 85-86
Published: 2001
Released on J-STAGE: September 07, 2009
JOURNAL FREE ACCESSDownload PDF (194K) -
2001 Volume 17 Issue 2 Pages 87-178
Published: 2001
Released on J-STAGE: September 07, 2009
JOURNAL FREE ACCESSDownload PDF (15602K)
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