Rhinocerebral mucormycosis generally occurs in immunosuppressive conditions such as uncontrolled diabetes mellitus and steroid therapy, and presents acute and aggressive clinical symptoms. Therapeutic strategies for rhinocerebral mucormycosis consist of control of the original immunosuppressive disease, surgery and medication. The prognosis of this condition depends on early diagnosis and treatment. Rhinocerebral mucormycosis rarely presents initial symptoms in the oral cavity. We experienced a case in which rhinocerebral mucormycosis was detected via maxillary osteonecrosis. We played a central role in providing treatment and saving the patient’s life, and his quality of life (QOL) was maintained. The patient was a 62-year-old man who visited our department with severe pain in the left upper molar region. His medical history included rectal cancer with metastatic lung cancer, type 2 diabetes, and coronary spastic angina. Gingival necrosis and sequestrums were observed in the left upper molar region seven days after his first visit. The diagnosis of mucormycosis was made based on micro-fungal biological and pathological samples. Following discussion with related clinical departments, we performed oral surgery twice and a physician provided medication via an antifungal drug. The patient recovered well following treatment. He has returned to work and has been maintaining his QOL over two years under routine follow-up.

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ヌクレオチドオクタマーの合成を考えるとき,二つのタイプのテトラマー(X型,Y型)をそれぞれ256種ずつ用意すればそれらの組み合わせ合成によって任意の配列のものを一段の合成でつくりうる。本研究ではこの原理を実現させるために,まず2型のテトラマーを実際に合成し,それを用いたオクタマーの簡便合成の検討を行なった。X型に,DMTrN1*pN2*pN3*pN4*Po-またY型に,HON1*pN2*pN3*PN4*bzを採用した。(ここで,DMTr,bz,*はそれぞれ保護基を示す)。テトラマー0.4μmoleのスケールで簡便合成を行なった結果,検討の範囲で収率は3～90%で,酵素的DNA合成法のプライマーとしては十分な収量と純度であることが示された。合成されたオクタマーのプライマー機能は,実際に酵素的DNA合成に用い,DNA中の特定の部位からの鎖伸長が行なわれることで確認された。本方法で合成されたDNAフラグメントは,プライマーリレー法のようなDNA塩基配列決定,DNAの識別や探索,遺伝子の発現調節などで広く有用である。そのさい,準備すべきテトラマーは512種の一部のみで間に合い,一般にテトラマーは効率的DNA合成の基本ブロックとしての最適サイズであることなどが考察されている。

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Hemophilia B is a disease in which the activity of blood coagulation factor IX (Christmas factor) decreases. A 22-year-old man was referred to our clinic by a local dental clinic. The medical and family history were irrelevant to the present disorder. The preoperative APTT value was 38.4 seconds, which was within normal limits. Four wisdom teeth had been extracted under intravenous sedation. On the first postoperative day, slight bleeding was observed from the left side of the upper jaw; this bleeding was controlled using an absorbable topical hemostat. The patient was discharged on the second day after surgery. However, repeated bleeding occurred from the fourth postoperative day, and the patient was re-hospitalized on the seventh day after surgery. The frequency of bleeding decreased gradually, and he was discharged from the hospital 12 days after surgery. The presence of a coagulation abnormality was suspected, and the patient was referred for hematological examination. He was given a diagnosis of hemophilia B based on the finding that the coagulation factor IX activity was reduced to 11%.

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Cooperative control algorithms for a finger-arm robot composed of a 3-DOF finger and 6-DOF arm have previously been proposed based on the movement of the human hand-arm system. In these algorithms, a finger-arm robot completes a constrained task by integrating admittance and impedance control with manipulability control of the finger. The finger manipulability is controlled both by an approximate global search, i.e., the top search method, and by a local optimization method. In this paper, these methods are developed further by relating them to dynamic movement. We also discuss the feasibility of virtual dynamics and clarify the dynamic characteristics in terms of the control algorithms. The dynamic characteristics are verified with virtual external force as shown in experiments with a redundant multi-finger-arm robot. Experimental results are presented for a multi-finger-arm robot to simultaneously achieve manipulability control and admittance control in a three-dimensional space. The developed methods responded to more dynamic movement.

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Solar transmittance τ_cl, reflectance ρ_cl and absorptance α_cl of eight different colors of clothing were measured. Solar transmittance increased and reflectance decreased with decreasing solar incidence angle to clothing. Solar absorptance was nearly constant regardless of solar incidence angle. The relationships between colors of clothing and solar transmittance, reflectance and absorptance were studied. Solar reflectance was expressed as a linear function of Munsell value regardless of hue and chroma. Solar transmittance, reflectance and absorptance were expressed as a function of luminance reflectance Y:τ_cl = 0.146 + 0.0017Y, ρ_cl = 0.320+ 0.0052Y, α_cl = 0.535 - 0.0069Y.

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This paper proposes an motion control issue for a redundant serial-linkage manipulator by stratifying degrees of freedom of the robot to number of fundamental motion blocks. Since the lightweight blocks near the end-of-arm actively moves using manipulability index, advantages like less driving power and improved dynamic performance can be expected in the proposed method. Experiment using a redundant manipulator comprised with a 6 DOF manipulator and a 3 DOF finger was made to demonstrate the effectiveness.

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The aim of this study is analytically to clarify heat transfer between combustion flame and the steel plate, that is to obtain heat flux, during line-heating process with both experiment and analysis.
Two dimensional temperature distribution within combustion flame is measured by laser induced fluorescence technique. For simplicity, jet instead of combustion flame is used to calculated temperature and velocity distributions. Using standard k-ε two equations model and assuming logarithmic law as wall function, convective heat transfer for turbulent flow is analyzed.
When the highest temperature within flame is used as temperature of jet at the nozzle exit, calculated temperature distribution of gas flow in near-wall region is similar to measured one. Measured and calculated time histories of temperature in the steel plate are in close agreement with each other. Numerical method to obtain heat flux is proposed during line-heating.

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Admittance control is one of effective methods when we realize flexibility of the robot finger. The admittance control is used for a finger-arm in order to simultaneously achieve the manipulability of the finger. Our previous studies show that damping effect of the admittance control can not be realized perfectly, which is related to the velocity. This paper shows both stiffness and damping effect of the admittance control and frequency characteristics of the finger system using more precise estimation method of both velocity and acceleration. Although the stiffness and the damping effects are not improved, experimental results of frequency characteristics can be improved in high frequency field.

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Complete atrioventricular （A-V） block is bradyarrhythmia caused by a failure of the atrioventricular conduction system. Careful attention during dental treatment is required so as not to cause adverse events, because patients with complete A-V block may easily develop circulatory failure by psychentonia. Complete A-V block is a very rare condition, and most patients with it receive a heart pacemaker implant. We report a case of complete A-V block without a heart pacemaker who underwent successful extraction of impacted mandibular wisdom teeth.
A female in her twenties consulted our department with complaints of pain and swelling in the region of the left lower impacted wisdom tooth. Her medical history was unusual, because she had been diagnosed with complete A-V block without a heart pacemaker caused by myocarditis in her childhood. Her electrocardiogram revealed a definite complete A-V block with bradyarrhythmia of 39/min. Under diagnosis of left mandibular pericoronitis of impacted wisdom tooth and right mandibular impacted wisdom tooth, we planned to extract both mandibular wisdom teeth using intravenous sedation to avoid excessive psychentonia. At the time of the surgery, her vital signs were heart rate of 37/min and blood pressure of 123/61mmHg. Just after application of local anesthesia with 2％ lidocaine with 1：80000 epinephrine, her heart rate rose to 60/min, but it immediately recovered to below 40/min. We were able to complete the operation without problems with an operation time of 40min.

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We report a case of hemophilia B in a patient with radicular cyst. A 65-year-old man was referred to our department because of a suspicious circular radiolucent finding in the right maxillary sinus. On further imaging, we found a cystic lesion measuring 32 mm × 30 mm and most likely arising from the apical area of the maxillary right second premolar. Extraction of the cyst and supplementation with coagulation factor were planned. At the time of surgery, we experienced difficulty in achieving hemostasis despite supplementation with coagulation factor, but we were able to stop the bleeding using absorbable oxidized cellulose and fibrin glue as hemostatic agents. Postoperatively, the bleeding recurred and persisted, for which we again administered coagulation factor, and the bleeding stopped completely. Subsequently, no further hemorrhage occurred, and the patient has been followed up for 10 months after surgery.

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