Synthetic detergents are becoming to be consumed largely in domestic life and in working places with the development of petroleum industry in Japan. And, numbers of housewives who complained of eczema of hand and visited the hospital have recently increased. Though the relationship between the use of synthetic detergents and the prevalence of eczema of hand in housewives had studied by some doctors, it has not been made so clear yet.
Therefore, health disorders, mainly those of hand skin, in the workers using large amount of synthetic detergents were studied. Observed subjects were 93 female workers for school lunch at 33 schools in Y city, and the control were 85 female teachers, clerks and others in Y city.
The results are as follows :
1) The workers for school lunch had significantly more complaints of roughness, thinness or loss of fingerprints, stiffness and exanthema of hand skin than the control. Disorders of hand skin in the workers for school lunch were characterized mainly by non-inflammatory changes such as hyperkeratosis, crevice formation, desquamation, etc. However, erythema of hand including those around nail were also found significantly more in the workers for school lunch than in the control. The disorders of hand skin in the workers might be caused mainly by contact with synthetic detergents for a long time, but they might have been deteriorated by mechanical and other chemical stimuli at washing tablewares or other hand works.
2) Disorders of hand skin were improved in summer and became worse in winter in both groups, but this tendency was more remarkable in the school lunch workers than in the control. And percentage of the workers for school lunch who had no complaint of hand skin during all seasons was only 9.7%, while that of those in the control was 35.3%.
3) Symptoms and signs of hand skin in some workers for school lunch were improved 3 weeks after soap was used instead of synthetic detergents, and the differences between both groups became not so clear. In spite of this, this might be due to insufficient data, and a further study is desirable.
4) In order to prevent the workers from disorders of hand skin, the working conditions should be so improved that the workers would not directly contact synthetic detergents or less toxic substance should be substituted for them.
5) The workers for school lunch had significantly more complaints of stiffness or dullness of shoulder, pain of neck and pain of the back than the control as revealed by the questionnaire compiled by the Committee on Neck-Shoulder-Arm Syndrome in Japan Industrial Health Association. It is thought that operations of washing the tablewares in the school might impose a heavy burden to shoulder, neck and the back of the workers.

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現在その原因の追求と慢性化の機序が問題となっている特発性心筋炎の剖検例24例(含心筋症との鑑別困難例3例)と,所見を比較するために併発性心筋炎(膠原病イソフルエンザ,敗血症,類肉腫等)16例を病理形態学的,一部の例に対しては電顕的,酵素組織化学的に,臨床的分類(大国)と対比しながら,検討した.急性経過をとり致命的な急性間質性心筋炎(Fiedler)とよばれるものは1)血管炎や肉芽腫性変化を伴うものと2)それらを伴わないものとに分けられ,前者は抗原抗体反応が,後者はインフルエンザ経過中の心筋炎に類似しウイルス感染が成因として推定される,病変の範囲,強さ,場所によっては炎症は遷延化し,慢性心筋炎への発展の可能性が十分考えられるが,心筋症との区別が困難な症例もある.24例中10例は15歳以下で小児期発病の頻度は高く,無症状突然死10例中9例は20歳以下の症例であった.

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Lymphadenosis benigna cutisの2例を報告し, さらに本邦報告例106例の統計的観察を試みた。症例1は30才男性で誘因なく左鼻翼部に半球状に隆起した表面平滑な紅色丘疹を生じ, 切除により以後再発をみない。症例2は20才女性で誘因なく右鼻翼部に半球状に隆起した弾性硬の赤褐色丘疹を生じた。生検施行後約1ヵ月の経過で自然消退し, 現在まで再発をみない。本邦例106例の男女比は1:2で女性に好発し, 好発年令は明らかでない。限局型と播種型の比は8:1であり外国例に比し限局型の頻度が高い。発生部位は顔面が82.7%を占めとくに鼻部·頬部に好発し, 形態は結節·丘疹が多い。臨床検査では異常は認められず, 病理組織学的にリンパ濾胞を呈するものが多く胚中心の形成もみられる。治療法としては放射線照射が多く用いられ有効であるが, 切除·摘出も行なわれている。また自然治癒もある。外国例に比し誘因は不明もしくはないものが大部分を占める。

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The renal vessels of the rabbit were ligated and its subpelvis connective tissue was daily explored for the mesenchymal system with toluidin-blue test by Kramer and Windrum method, from the next day of the ligation to the 170th day.
The results obtained are as follows:
1) On the first day after the ligation, an infiltration by histocytes is seen in the connective tissue directly underlying the epithelium.
2) On the 5th day, β-metachromasia and numorous infiltrations by lymphocytes, eosinophilic leukocytes, histocytes and fibroblasts are observed in the subepithelial and sumbmascular connective tissues.
3) On the 9th day, the cells showing α-metachromasia become pronounced.
4) On the 10th day appear many phagocytes.
5) On the 20th day appear a number of foreign body giant cells, whereas ather cell infiltrations are on the decrease.
6) On the 30th day, a bone formation is recognized under the hyperplastic epithelium.
7) On the 35th day is seen a bone tissue with bone marrow capable of hematopoiesis.
8) On the 45th day, the bone tissue is extended to the medulla of the kidney.
From the facts above mentioned, it is presumed that it is not the mesenchymal remannts but the mesenchymal reaction under the epeithelium and the muscular layer of the renal pelvis, caused by ligation of the renal vessels, that plays a standing role in metaplasia of the bone.
It should be suggested here that heterotopia of a smooth muscle in the urinary tract after a plastic surgery on that region, which constitutes a smiliar condition to the foregoing experiment, may be attributed to the same mechanism.

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The histological features of lichen planus are hyperkeratosis, hypergranulosis, irregular acanthosis, liquefactions degeneration of the basal cell layer and band like lymphoid cell infiltration in the upper dermis. On the other hand, these histological changes are cosidered as a reaction cutaneé against the various etiologies. The subject of this report to study the pattern of the tissue reactions in lichen planus and lichenoid eruptions using the term of lichenoid tissue reactions. The histological studies were carried out on the 22 specimens from 12 cases of lichen plauns, 2 of them being of the oral mucosa and the lip and the 4 specimens from 2 cases of lichenoid eruption due to color developer and hypotensive agents. The results obtained were as follows. Epidermal findings; In the early stage, the epidermis showed slight edematous changes, inter cellular edema, vacuolation of prickel cells and basal cells, and accompanied the involvement of basement membrane. As the disease progressed, liquefactions degeneration of the basal cell layer became more obviously, the prickel cells hypertrophied and the epidermis showed pseudoacanthosis. These changes may be a sign of adaptation to keep the homeostasis of the epidermis against the various detriments such as epidermal nutritional insufficiency and abnormal metabolites produced in the dermal lesions. When the balance was disturbed, the epidermis revealed degenerative changes, atrophy and even necrosis. In the advanced lesions, occasionaly, regeneration of the epidermis was noticed and the epidermis showed true acanthosis and occasionally slight parakeratosis. Hyperkeratosis were distinctive findings of this disease. They were a sign of retention of the epidermal cells resulted from supression of the mitosis which was caused by undernutrition of the epidermis. Dermal findings; In the early stage, nonspecific mild inflammation was noticed in the area of the subpapillaries. The infiltrated cells were polymorphous; a few neutrophils, eosinophils, mast cells and moderate lymphocytes. Typical lesions showed marked dilatation and toutous meadering of the capillaries and dilatation of the lymphcapillaries. They are a sign of microcirculations failure, which is a significant element of the histgenesis of this disease. The continuous microcirculations failure elicite reactive lymphoreticular cell hyperplasia. The process of lichenoid tissue reaction can be assumed as follows. When there is reduction in biological activity of the epidermis as a diathesis, the mild inflammation, which may be a certain allergic reaction in the area of the subpapillary pulls the trigger of microcirculations failure. It elicite hypertrophy, degenerative changes and regeneration of the epidermis. These various changes are intermingled in the same lesion and at the same time. This characteristic tissue reaction may be occured on the basis of lichen diathesis. In two specimens, enlargement of the nerves were observed. Involvement of the nerves may be one of the significant element of lichen diathesis. Lichenoid eruptions due to color developer and hypotensive agents showed the same tissue reactions. Ten specimens from 8 cases of melanosis Riehl were observed histologically. They showed similar process of the reaction to that of lichen planus, but lymphoreticular hyperplasia and toutous meandering of the capillaries were not striking. The degeneration of the collagen were remarkable, in two of them hyaline depositions were observed in the papillary region.

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当科のfollicular mucinosis17例の特徴をまとめた。男性6例, 女性11例で女性に多く, 年齢分布は幅広いが40代にピークを有する。掻痒を伴うものは約半数, 8例にみられた。好発部位は顔面で, 17例19部位のうち13部位を占めた。臨床像はfollicular-papular type6例, plaque-type9例, その他2例で, 臨床診断は多岐にわたった。病型では, リンパ網内系疾患を伴うgroup3が2例見られ, 合併疾患はそれぞれHodgkin病とmalignant lymphomaであった。
代表症例5例を供覧し, 本邦報告例と合わせて110例についても集計した。

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皮膚血管腫の個々の病型の本態を明らかにし, 病型相互間の異同を指摘し, 出来うれば将来の新らしい分類を試みる目的でもって, 電子顕微鏡的に研究をおこない, 先に, 赤ブドー酒様血管母斑について報告した.
本編では毛細血管拡張性肉芽腫32例 (光顕的組織分類第I型14例, 第II型13例, 第III型5例) を観察し, 次の結論を得た。本症の組織発生機序として炎症性肉芽腫説と血管腫瘍説の2つが論じられているが, 本研究の微細構造の所見より, 本症は他の血管性腫瘍と並列されるべき一種の遅発性血管腫であることを確認した。

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