We studied serum lipids and lipoproteins of healthy lean subjects. Those are total cholesterol (T. Chol), triglycerides (T-G), high density lipoprotein cholesterol (HDL-C), low density lipoproteins (LDL) and very low density lipoproteins (VLDL).
The data from 7, 952 were reviewed who had had medical check-up between April 1980 and April 1986. Of them, chosen were those who were in good health and weighed less than 80% of desirable weight for Japanese. They included 61 men and 53 women. Almost all of the men had habits of daily smoking and drinking, while all of the women did not. Healthy controls were also chosen from the same population, who weighed 95 to 105% of the desirable weight. They included 61 men matched with the lean male subjects for age, and daily consumption of cigarette and alcohol, and 141 women who did not smoke nor drink. The range of age was 30 to 69 years for men and 20 to 69 years for women.
Healthy lean subjects of both sexes were found to have significantly lower values of T-G and VLDL (p<0.01), and significantly higher ones of HDL-C (p<0.001). LDL levels tended to be lower than those of controls. No significant differences were noted in the levels of T. Chol. The data from subjects divided into groups of each 10 years of age showed the same tendency as the above-noted results. LDL levels were shown to have a weak linear correlation with age (r=0.48 in lean, and r=0.41 in controls).
The results of lipids and lipoproteins in our study of lean subjects would be considered to be in a mirror-image of those obtained from obese subjects by other investigators.
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