私の医学の研究は概ね3期に分けることができる. 第1期は温泉の各種生体機能への作用, つまり生体に対する温泉作用の本態の究明, 温泉の治病機転の解明であり, 第2期は温泉に関係の深い疾患としてリウマチをとり上げ, リウマチに対する温泉作用から出発してリウマチ, 膠原病の臨床的研究へ, そして第3期は温泉を理学療法の一つとして捉え, 理学療法を主な治療手技とするという立場からリハビリテーション医学へのアプローチということになる. 温泉医学, リウマチ膠原病学, そしてリハビリテーション医学, その何れもが当時の医学の領域では日のあたらない未知の分野であり,「見於未萠」の一語に尽きる. いわばその開拓者の役割を果してきたといえる.
本講演では, そのうち私の「温泉の医学的研究」を一つのモデルとして, 私自身の医学における研究の進め方, というより進み方を紹介し,「研究とは何ぞや」について私の考え方を述べ, 若い研究者に捧げたい.

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We assessed the clinical usefulness of ketoprofen (150 mg/day) comparing with aspirin (3 g/day) by a double blind controlled study. The anti-inflammatory effect of 150 mg/day of ketoprofen is equivalent to 3 g/day of aspirin which is a high dose for the average Japanese. Side effects of ketoprofen, however, are much less than those of aspirin as for the degree and frequency.
We confirmed the clinical usefulness of ketoprofen as an anti-inflammatory agent.

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At Imagami Spa in Yamagta Prefecture, consultations on balneal treatments and some medical researches were carried out side by side with a general survey of balneal treatments (August, 1965). Imagami Spa is located in a remote mountain and has been known as “the Spring of God”. There is only one hotel in Imagami Spa, which is open to the genenal public as soon as the snow melts away. Primitive log houses are set up when visitors come not for pleasure but only for balneal therapy. Most of the visitors are from Yamagata Prefecture of whom the aged are large in number. Of the female visitors, those who are engaged in farm work are the largest in number. The largest number of visitors come to this Spa for therapeutic treatment and convalescence, which shows clealy the nature of this Spa. The classification of diseases shows that the visitors are mostly suffering from gastro-enteropathy, neuralgia and cardiovascular diseases. Very few visitors come to this Spa under a doctor's prescription. About 90% of the visitors stay there for more than two weeks; visitors are characterized by long-term balneal tneatment. In general, the visitors tend to bathe excessively and for a long time. About 89.1% of the visitors drink hot spring, water which frequency is greater here than in any other hot spring resorts and which is a rare case in Japan. About 48.9% reported that the balneal treatment was effective and 47.8% replied that it was not clear. Bathing reaction was observed in 29.3% and comparatively large numbers of visitors complained of constipation, fatigue and dermatitis. It was found from Cornel Medical Index (CMI) that 31.3% of the total number of visitors showed characteristic of complaints of the neurotics or neurotic patients, which shows that this Spa is favored by this kind of patients. This Spa proves to be of interest when we take into account the fact that the visitor has a sort of religious faith in this Spa.

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