Compatibility tests on ketoprofen injection (Kp) with eight local anesthetics (LA) were performed in terms of pH, appearance, osmotic pressure against aline, and residual Kp after mixing.
For admixing, following two methods were used.
Group A: Kp is dissolved in distilled water for injection and then admixded with LA. Group B: Kp is directly dissolved in LA. The results are as follows:
1. Mixing with following drugs should be avoided:
Group A: Percamin S, Carbocain (2%), Xylocaine E (1 and 2%), Marcain (0.25 and 0.5%), Citanest (1 and 2%). Group B: Bancain (2%), Percamin S, Carbocain (2%), Xylocaine E (1 and 2%), Xylocaine (3%), Marcain (0.5, 1 and 2%).
2. Mixing with following drugs should be made with caution.
Group A: Bancain (2%), Calbocain (1%), Xylocaine (1, 2 and 3%), Xylocaine E (0.5%). Group B: Xylocaine (1 and 2%), Xylocaine E (0.5%).
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