145 flavonoids were studied for their inhibitory effects on the ironinduced lipid peroxidation in mitochondria obtained from rat livers. Of these compounds tested, 30, 57, 59, 67, 70, 72, 77, 102 and 110 (ED
50≤0.5nmol/mg prot) showed distinctly more potent inhibitory activity than baicalein (ED
50≤5nmol/mg prot) and 59 and 72 (ED
50≤0.05nmol/mg prot) exhibited the most potent activity. In order to elucidate the relationships between substituents on the flavonoid skeleton and the biological activity, the quantitative structure-activity relationships (QSAR) were analyzed by the adaptive least-squares (ALS) method for 142 flavonoids. The analysis has shown that the presence of the 1, 4- and 1, 2-hydroquinon in A-ring and/or B-ring of flavonoids and hydrophobicity of the molecule are responsible for the in vitro inhibitory activity.
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