As the first report of this series attempted to unveil the hitherto little known status of rubella infection in Japan, the authors presented here the results of a sero-epidemiological survey performed on inhabitants of Kumamoto city.
In that, serum samples were collected non-selectively from a total of 410 persons who visited the affiliated hospital of the Faculty of Medicine, Kumamoto University for whatever kind of laboratory tests between Jan. and Aug. in 1965. These sera were subjected to detections of neutralizing antibody to rubella virus.
The results were summed up as follows:
1. Possessing rate of the positive neutralizing antibody by age distribution: An appreciable rise of the rate started at 10 years of age, and reached a peak (about 60% at the highest) between 15 to 19. This figure is considerably lower* than reported statistics of large cities such as Osaka and New York.
Moreover, the rate was extremely low in such age brackets as 0-4 and 5-9. This suggests that there has been no epidemic of appreciable size in this city in the past ten years.
2. The antibody possessing rate by sex: In any age group, differences of worth mentioning by sex were not observed.

抄録全体を表示

A very rare case of polycranialneuropathy after rubella infection in a 40-year-old woman is described.
She was admitted to hospital with sudden deafness. One week previously she caught cold and had a slight fever, sneezing and nasal discharge. Three days before this, she had had a rash which appeared all over her body, especially over the extermities and abdomen. The rubella antibody titer was 1:256. One month later she complained of vertigo with severe rotato-horizontal nystagmus and one week thereafter unilateral facial paresis appeared suddenly. She was treated with intensive drug therapy and made a gradual but slow improvement during hospitalization At the time of discharge one-and-a-half months after admission, she still had moderate hearing impairment without vertigo or facial paresis. No other case of polycranialneuritis after rubella was found in the literature.

抄録全体を表示

Three strains of rubella virus could be isolated with primary African green monkey kidney (GMK) cell from the throat swab specimens of rubella patients during the epidemic at Osaka district in the spring of 1966. One of these newly isolated strains has been serially cultivated for at least 11 passages in the amniotic cavity of a developing chick embryo.
The chicken egg adapted strain was rather sensitive to temperatures as compared with other strain which was passaged only in GMK cell several times after isolation.
It was experimentally inoculated into cynomolgus monkeys at the 6th and 11th passage level and both produced sufficiently high NT (neutralization) and HI (hemagglutination-inhibition) antibody responses without any recognizable symptoms, although there were a little virus recoveries from the throat of some monkeys at both passage levels.

抄録全体を表示