This study investigated differences in periodontal health variables between buccally impacted maxillary canines (BIMC) and palatally impacted maxillary canines (PIMC) after surgical-orthodontic treatment with open technique. Nineteen patients were enrolled: 10 with unilateral BIMC (5 men,

; mean age 18.50 ± 1.96 years) and 9 with unilateral PIMC (4 men, ; mean age 19.44 ± 2.40 years). Probing depth and keratinized tissue were recorded 12 months after surgical-orthodontic treatment, and the differences between the 2 sides were analyzed as primary outcomes. In addition, data for BIMC and PIMC were directly compared. In the BIMC group, probing depths were significantly higher for lateral incisors than for the untreated side (P = 0.044), and keratinized tissue values were significantly lower for canines than for the untreated side (P = 0.006). No significant differences were observed in the PIMC group. In BIMC, surgical-orthodontic treatment with open technique resulted in loss of periodontal keratinized tissue in the treated tooth and periodontal attachment loss in adjacent lateral incisors. However, the periodontal status of PIMC was not affected by surgical-orthodontic treatment with open technique.

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A clinicopathological study was made on 6 cases ( and a man) of so-called functional aortic regurgitation. A new etiological concept was proposed for this category of aortic regurgitation as degenera-tive type due to a prolapse of the posterior cusp of aortic valve. Prolapse of the cusp was explained by an interruption of the transverse ridge due to fibrinoid, hyalinoid, atheromatous or calcified lesions.

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Hypothalamic decapeptide, gonadotropin-releasing hormone (GnRH) has been found to stimulate human chorionic gonadotropin (hCG) secretion by trophoblast cells in vitro. To determine the biological effect of GnRH on the release of hCG in vivo, we studied the effect of the administration of GnRH on the serum levels of human chorionic gonadotropin (hCG) during pregnancy. Serum hCG levels were measured before and 15, 30, and 60min after the intravenous administration of 100μg of GnRH to 22 volunteers with normal pregnancy. Nine of the 12 (75%) women responded to GnRH in the first trimester, while only 1 of the (20%) responded to GnRH in the second trimester. None of the tested in the third trimester showed a significant response of hCG to the injection of GnRH. The average increase in hCG during the first, second and third trimester was 160.7±13.5%, 111.0±7.4% and 95.0±2.3%, respectively (mean±SEM). Whereas the pregnant courses of all the cases were uneventful and normal, other abnormal pregnancies were also investigated with informed consents. Three patients with missed abortions also showed a significant response of hCG to GnRH (increase: 136.7±8.5%) when GnRH was administered before curettage of the uterine cavity. However, 4 patients with unruptured ectopic pregnancies did not respond to GnRH stimulation. These findings indicate that GnRH can stimulate the release of hCG by the placenta in vivo, consistent with the previous in vitro study, while the responsiveness depends on gestational age and the implantation site.

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Treatment regimens for frozen shoulder vary. These include joint distension which is performed in conjunction with the arthrography of the shoulder. Distension arthrography was performed in 19 cases from April 1997 to March 1998, of which nine cases (4 men, ) were available for this study. One case underwent surgical manipulation after joint distension. One case was admitted for surgery but joint distension on the day of admission was so effective that she discharged without surgery. The average JOA score was 55.4 before this procedure and 84.1 at the time of follow-up. As the treatment for frozen shoulder, we recommend this procedure before surgery.

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The chemical assay of urine pregnanediol, estriol, estradiol and estrone of 25 pregnant women 3 to 5 days before parturition 8 women of 7 months pregnancy, of 6 months pregnancy and of 5 months pregnancy, together with the histological and histochemical studies of the placenta was carried out with the following results. The Stimmel method (1952) was used for the quantitative analysis and the Sudan, Schiff, Ashbel-Seligman and Schultz stain was used for the histochemical studies.
I) Up to the fifth to sixth month of pregnancy, all the syncytial cells have the ability to secrete progesterone and estrogen, but from the seventh month the general syncytial cells start to loose this ability and by the tenth month ability to secrete steroids is lost with only the knobs of nucleated syncytium retaining this function. This view is based on the following facts.
1) In the fifth and sixth month of pregnancy, both the general syncytial cells and the knobs of nucleated syncytium show no degeneration and are positive to carbonyl stain. 2) The general syncytium, from the seventh to thnth month of pregnancy, shows a progessive degeneration and is negative to carbonyl stain. 3) The knob of nucleated syncytium through the seventh to tenth month shows no histological changes from the fifth month, and remains positive to carbonyl strain. 4) The per unit progesterone and estrogen secretion of the syncytial cells decreases with the progress of pregnancy. 5) The knobs of nucleated syncytium increase toward the termination of pregnancy. 6) The knobs of nucleated syncytium in the tenth month placenta and the unit placenta weight 24 hour urine pregnanediol and estrogen have correlation coefficent of 0.68 and 0.39, thereby sho wing a correlation.
II) The weight of the tenth month placenta and the 24 hour urine pregnanediol show a correlation coefficient of 0.58, and the 24 hour urine estrogen 0.48, thereby showing a correlation.

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In order to find informative salivary biomarkers specific to oral cancer we examined expression of 4 kinds of cytokine in saliva. Levels of interleukins (IL-1β, -6, -8) and osteopontin were measured by ELISA using whole saliva samples collected from 19 patients with oral cancer (9 men, 10 women; mean age, 60.9 years) and 20 healthy persons (15 men, ; mean age, 32 years). Expression of the 4 cytokines was higher in patients with oral cancer than in healthy controls. The difference was significant in IL-6, in particular. The results suggest that saliva offers a potential target for a screening test aimed at detection of precancerous lesions.

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Neurogenic claudication caused by exercise but relieved by rest is usually reliable symptom of lumbar spinal canal stenosis. 12 patients with lumbar canal stenosis were studied. They ranged in age from 64 to 85 years (mean, 74.5). There were 7 men and . These 12 patients were evaluated with treadmill exercise testing and spinal cord evoked potential after electrical stimulation to the tibial nerve trunks, caudal epidural anesthesia. In all of 12 patients, both electrical stimulation to the tibial nerve trunks and caudal epidural anesthesia significantly prolonged onset time of claudication.
In 10 of 12 patients, the amplitudes in spinal cord evoked potential significantly decreased after treadmill exercising and recovered in 5 minutes.

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During the period from October 1986 to April 1988, arthroscopic synovectomy for rheumatoid arthritis of the ankle was performed on 9 ankles in 6 patients.
Follow-up evaluations were possible for a total of 7 ankles in with a mean age of 58.2 years (range, 43-71 years).
There were 5 patients in classical RA.
Postoperative follow-up study was performed by personal interviews in our clinic at the final follow-up evaluation, which averaged 15 months, with a minimum of 9 months.
In the evaluation by the patients, results were excellent in 2 ankles (28.5%), good in 5 ankles (71.5%).
Arthroscopic synovectomy of the ankle joint can be recommended as a useful therapy for many patients with rheumatoid arthritis of the ankle.

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Surgical specimens from 5 men and with extramammary Paget's disease were examined for erbB4 and progesterone receptor expressions using immunohistochemical methods. The positive staining was observed only in tumor cells of Case 3, when anti-erbB4 antibody was used. Because Case 3 stayed in the non-invasive stage of extramammary Paget's disease, it seems unlikely that erbB-4 positivity in tumor cells of extramammary Paget's disease may correlate with a poor prognosis. No positive staining was observed when the nine extramammary Paget's disease specimens were stained for progesterone receptor. These results may indicate that extrammary Paget's disease has an essentially different nature from that observed in breast carcinoma.

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We reviewed the results of operative treatment in 32 patients with lumbar disc herniation in adolesence. During 1991-1996 we operated on 18 patients (13 men, , mean age at surgery, 16.4 years) with percutaneous discectomy (PD); 14 patients (10 men, 4 women, mean 15.5 years) with open discectomy. The post operative results, were excellent or good in 11 of 18 patients (61.1%) with PD, and in 13 of 14 patients (92.5%) with open disectomy, respectively. The average period of recovery to playing sports was 1.75 months with PD, 2.90 months with open disectomy. One of the important things in surgical treatment of lumbar disk herniation in adolesence is the period of recovery to full sporthing activities. In this study, it is suggested that PD is the most useful treatment for lumbar disk herniation in adolesence.

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We investigated the feasibility of combining the active contour model with gradient vector flow (Snakes-GVF) to estimate left ventricular (LV) volumes from cardiac cine magnetic resonance imaging (MRI). MRI data were acquired from 27 patients, including 14 adults (9 men, , 55.0±23.3 years) and 13 children (10 boys, 3 girls, 2.7±2.1 years) using Gyroscan Intera (1.5 Tesla, Philips Medical Systems). LV volumes were calculated by adding the areas surrounded by the contour extracted by Snakes-GVF and compared with volumes estimated by manual tracing. Those estimated by Snakes-GVF [y (mL)] correlated well with those estimated by manual tracing [x (mL)]. In adult cases, the regression equation and correlation coefficient were y=1.008x-0.517 and 0.996, respectively. In pediatric cases, they were y=1.174x-2.542 and 0.992, respectively. In conclusion, Snakes-GVF is a powerful and useful tool for quantifying LV volumes using cardiac MRI.

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A boy, aged 10, showed an abnormal eruption of an incisor in the right nasal cavity.
Including our case, there were 126 cases, involving 131 teeth, of dental abnormalities reported in the literature of this country.
Statistically, there were 8 men and , more cases involving supernumerary teeth than normal teeth, more teeth. Involving permanent than deciduous teeth, more involving the incisors than canines and more in the left nare than the right.

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[Purpose] The purpose of this study was to determine the effects of a 4-week program of active condylar rotation exercise on the extent of the lateral mandibular shift during mouth opening in patients with temporomandibular disorder. [Subjects and Methods] Patients with temporomandibular disorder (n = 12; 7 men and ) were recruited. The active range of temporomandibular motion was recorded using 3-dimensional ultrasound-based motion analysis. The paired t-test was used to assess changes in lateral mandibular shift before and after active condylar rotation exercise. [Results] The degree of the lateral mandibular shift during mouth opening and the mouth opening-lateral mandibular shift ratio were significantly lower after active condylar rotation exercise than before the exercise. [Conclusion] Active condylar rotation exercise may effectively reduce the degree of the lateral mandibular shift during mouth opening to produce symmetrical mouth opening in patients with mild temporomandibular disorder.

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In this study, we report the clinical differences between osteosarcomas arising in elderly patients and those in children and adolescents. Since 1978, we have treated 9 patients with osteosarcoma occurring in patients older than 40 years. Four men and were affected, with a mean age of 56.6 years, ranging from 48 to 76 years of age. In contrast to osteosarcoma in children and adolescents, where 75% of the tumors arise around the knee, this region was involved in only 33% of the elderly patients. The percentage of patients with elevation of serum alkaline phosphatase levels was significantly higher in older patients compared with younger patients (78% versus 39%: p<0.05). Seven of g patients were treated with radical surgery. Although preoperative chemotherapy was used for only 44% of patients, 5-year survival estimates of the elderly patients were 66.7%. No significant differences in the survival rates were observed between elderly patients and children.

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The "KIN PEI BAI" is known as one of the four most valuable books in Chinese classical literature and is said to be written in the middle of Banreki years of the Ming period. In this paper the order maintained by a wealthy feudal family is examined in relation to the room arrangement, considering the relationship between the ceremony of marriage, one of the ritual initiations, and women's territory. Consequently next five points become clear: 1) The territory of women is divided according to their status in a house, such as a wife, a mistress and a maid. 2) A woman's room is divided by fences and walls, and is also isolated from a society. 3) Special furniture is installed in a salon and a woman's room, when they are changed to a place of a ceremony. 4) As for pictures in folding screens, a public room is mainly arranged with "Sansuiga", and others are also arranged with "Kachouga". ) territory in a house is "like a Utopia" for a man.

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Magnetic resonance imaging has increased the incidence of the diagnosis of intramedullary cavernous angioma. Surgical therapy tends not to be recommended for asymptomatic lesions, but symptomatic lesions that bleed recurrently should be treated. The natural course of intramedullary cavernous angioma remains unknown and arguments have been raised against the surgical treatment of symptomatic lesions. We reviewed the clinical features of 13 intramedullary cavernous angiomas in 12 patients surgically treated between 1988 and 2009. The 7 men and were aged from 14 to 60 years, the preoperative interval ranged from 0 to 161 months, and the mean number of hemorrhages in the 13 lesions was 2.5. Sixteen operations were performed to treat the 13 lesions. The surgical approach depended on the lesion location. The outcome of patients with mild to moderate preoperative symptoms (McCormick grades I-III) was significantly better than that of patients with severe symptoms (McCormick grade IV) (p < 0.05). Symptomatic intramedullary cavernous angioma tends to bleed repeatedly. The lesion should be surgically removed to avoid further deterioration due to recurrent hemorrhages. The shortest path approach should be selected based on preoperative images and complete removal should be attempted. Residual lesion may be masked by surrounding gliosis, so careful postoperative follow up is necessary.

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【Background】As specialized pro-resolving mediators (SPM) derived from fatty acids are detectable in synovial fluids in osteoarthritis (OA), they appear to take some roles for disease pathogenesis. Receptors for SPMs have been found, such as leukotriene B4 receptor (BLT1), formyl peptide receptor 2 (FPR2), and chemokine like receptor 1 (CMKLR1). 【Purpose】To identify the significance of receptors for SPMs on the cells in synovial tissue from OA joints. 【Methods】Expression of BLT1, FPR2 and CMKLR1 on synoviocytes from OA patients (45.% , mean age 69 years, mean BMI 27.9 kg/m²) and macrophage were analysed by flow cytometry and quantitative PCR. 【Results】FPR2 and CMKLR1 are found on synoviocyte, in which mean expression by flow cytometry were 8.5% and 6.2%, respectively, but BLT1 was less than 2.0%, although all of them decreased by keeping incubation. LPS treatment increased rather FPR2, but not so much CMKLR1, on synoviocytes and macrophage. 【Conclusion】There are FPR2 or CMKLR1 positive cells in synovial tissues, and especially FPR2 seems to have a certain function under inflammatory conditions.

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Background and Methods Changes in serum total cholesterol levels associated with aging in young adults were compared with those in the elderly. Changes in serum total cholesterol levels in 117 patients aged less than 35 years old and 38 patients at least 55 years old who underwent physical examinations in 1992 were compared over 10 years until 2002.
Results Serum total cholesterol in the group of young adults with normal cholesterol levels of 220 mg/dl or less in 1992 rose significantly, while it remained high in the group with high cholesterol levels of 221 mg/dl or more. However, serum total cholesterol levels did not change in the elderly group with normal cholesterol levels, while the levels in the high cholesterol group tended to decrease.
Conclusion These results suggest that young adults with high serum total cholesterol are exposed to a condition of continued hypercholesterolemia over the long term, indicating that active health education is important from an early age.

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