抄録
Surgical specimens from 5 men and 5 women with extramammary Paget's disease were examined for erbB4 and progesterone receptor expressions using immunohistochemical methods. The positive staining was observed only in tumor cells of Case 3, when anti-erbB4 antibody was used. Because Case 3 stayed in the non-invasive stage of extramammary Paget's disease, it seems unlikely that erbB-4 positivity in tumor cells of extramammary Paget's disease may correlate with a poor prognosis. No positive staining was observed when the nine extramammary Paget's disease specimens were stained for progesterone receptor. These results may indicate that extrammary Paget's disease has an essentially different nature from that observed in breast carcinoma.
