Ground mixtures of Florae
®, RE (FR) (porous calcium silicate) and acetaminophen (
ACTA
) were prepared in order to improve the dissolution and compression characteristics of
ACTA
. No diffraction peaks due to
ACTA
crystals were observed in the powder X-ray diffraction pattern of the ground mixture with FR (FR:
ACTA
=9: 1), which showed amorphization of
ACTA
crystals caused by grinding. The ground mixture produced an improved dissolution of
ACTA
in comparison with the
ACTA
crystals, and the tablets prepared from the ground mixture showed faster dissolution behaviour of
ACTA
than the tablets prepared from a physical mixture.
Tablets of ternary ground mixture containing FR,
ACTA
and polyethylene glycol 6000 (PEG 6000) were prepared. The dissolution profile of
ACTA
from the tablet was found to be controlled by the PEG6000 content and compression pressure.
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